BACKGROUND AMG 416 is a novel peptide agonist of the calcium-sensing receptor (CaSR). This report describes the activity of AMG 416 in two different rodent models of uremia, compared in each case to cinacalcet, an approved therapeutic for secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease on dialysis. METHODS AMG 416 was administered as a single intravenous (IV) bolu...

We present new VLA C-configuration H i imaging of the Lyα-emitting starburst galaxies Tol 1924−416 and IRAS08339+6517. The effective resolution probes neutral gas structures larger than 4.7 kpc in Tol 1924−416, and larger than 8.1 kpc in IRAS08339+6517. Both systems are revealed to be tidally interacting: Tol 1924−416 with ESO338−IG04B (6.6 = 72 kpc minimum separation), and IRAS08339+6517 with ...

We conducted a yearlong prospective study of febrile patients admitted to a tertiary referral hospital in Chittagong, Bangladesh, to assess the proportion of patients with rickettsial illnesses and identify the causative pathogens, strain genotypes, and associated seasonality patterns. We diagnosed scrub typhus in 16.8% (70/416) and murine typhus in 5.8% (24/416) of patients; 2 patients had inf...

عاطقلا طبر ي يذ لا ة يبرهكلا ىو قلا ماظنل يكيمانيدلارارقتسلال ةضيفتسم ةيلمع ةسارد ثحبلا اذه مدقي ني ب ة لوقنملا ةرد قلا ةدا يز ى لع ك لذ ريثأ ت و ةيدوعس لا ءا برهآ ةآر ش ن م ط سولأا عا طقلا و يقرش لا نيعاطقلا ، ىوقلا مظن تاتبثم طبض للاخ نم كلذو . دقل شم ةغايص مت ةلك طبض ةروص ىف تاتبثملا هذه ةلثمأ ةلكشم . ماظنلا ءادأ نيسحتل ك لذو ةدر فنملا ماظنلا ميق ىلع نادمتعت فده يتلاد حارتقا مت دقلو . د قلو ...

416 BioScience • May 2014 / Vol. 64 No. 5 http://bioscience.oxfordjournals.org BioScience 64: 416–428. © The Author(s) 2014. Published by Oxford University Press on behalf of the American Institute of Biological Sciences. All rights reserved. For Permissions, please e-mail: [email protected]. doi:10.1093/biosci/biu038 Advance Access publication 16 April 2014 Shade Coffee: Update on a...

*Marshall, K Wayne (A); *Staples, J; +**Damyanovich, A *Department of Surgery, Division of Orthopaedics,The Toronto Arthritis Centre,Toronto Western Hospital and the Unversity of Toronto, Toronto, Ontario, Canada. +**Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. Toronto Western Hospital, Mc 14-409,\399 Bathurst St.\Toronto, Ontario, Ca...