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Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors (HDACi) could attenuate hepatic steatosis through glucocorticoid receptor (GR) acetylation in experimental CS. To induce CS, we administered adrenocorticotropic ho...
Each Gr-category (or categorical group) is Gr-equivalent to a Grcategory of type (Π, A, ξ), where Π is a group, A is a Π-module and ξ is a 3-cocycle of Π, with coefficients in A. In this paper, first we show that each Gr-functor induces one between Gr-categories of type (Π, C). Then we give results on the existence of Gr-functor and the classification of Gr-functors by cohomology groups H(Π, C)...
This work describes the synthesis of few-layer graphene sheets embedded with various amounts of gold nanoparticles (Gr-Au-x) over an Aux/MgO catalytic system (where × = 1, 2, or 3 wt%). The sheet-like morphology of the Gr-Au-x nanostructures was confirmed by transmission electron microscopy and high resolution transmission electron microscopy, which also demonstrated that the number of layers w...
MOTIVATION Protein structure alignment is key for transferring information from well-studied proteins to less studied ones. Structural alignment identifies the most precise mapping of equivalent residues, as structures are more conserved during evolution than sequences. Among the methods for aligning protein structures, maximum Contact Map Overlap (CMO) has received sustained attention during t...
Abstract Reactive synthesis is an automated procedure to obtain a correct-by-construction reactive system from its temporal logic specification. GR(1) expressive assume-guarantee fragment of LTL that enables efficient and has been recently used in different contexts application domains. A common form providing system's requirements through use cases, which are existential nature. However, GR(1)...
We have screened a panel of tetracycline (tc)-like compounds for their potential use with tc-repressor (tetR) based gene switches. The interaction between tc and tetR appears quite specific, as only tc itself and its close homologues anhydro-tc and doxycycline strongly inhibited DNA binding. However, a single tc-like compound, GR33076X, increased DNA binding of the tetR-VP16 fusion protein, bot...
BACKGROUND High-dose chemotherapy (HDT) was added to conventional chemotherapy in Ewing sarcoma family tumor (EFT) patients, poor responders (PRs) to induction chemotherapy in order to improve their survival. PATIENTS AND METHODS Patients aged ≤40 years with nonmetastatic Ewing sarcoma (ES) received vincristine (V), doxorubicin (A), cyclofosfamide (C), actinomycin (Ac), ifosfamide (I) and eto...
BACKGROUND Patients with compensated Child-A cirrhosis have sub clinical hypovolemia and diuretic treatment could result in renal impairment. AIM To evaluate the changes in renal functional mass as reflected by DMSA uptake after single injection of intravenous furosemide in patients with compensated liver cirrhosis. METHODS Eighteen cirrhotic patients were divided in two groups; eight patie...
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