A series of 6-substituted 2-benzoxathiine-2,2-dioxides were synthesized starting from 2,5-dihydroxybenzaldehyde, and then screened in vitro for their inhibition properties against five human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms. All the compounds showed excellent selectivity against the mitochondrial (hCA VA) and the tumor associated (hCA IX and XII) enzymes.

We have screened toyocamycin as an inhibitor of phosphatidylinositol kinase. It inhibited the enzyme of A431 cell membrane with an IC50 of 3.3 micrograms/ml. Adenosine and formycin A also inhibited the enzyme, but other 6 related nucleosides did not. Although orobol and 2,3-dihydroxybenzaldehyde that inhibit phosphatidylinositol kinase inhibited in situ phosphatidylinositol turnover, toyocamyci...

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus with 12-30% fatality rate. Despite severity of the disease, any medication or treatment for SFTS has not developed yet. One approach to prevent SFTS spreading is to control the arthropod vector carrying SFTS virus. We report that 2-methylbenzaldehyde analogues from M. officinalis have a dua...

A common consequence of using agricultural fungicides is the development of resistance by fungal pathogens, which undermines reliability of fungicidal effectiveness. A potentially new strategy to aid in overcoming or minimizing this problem is enhancement of pathogen sensitivity to fungicides, or "chemosensitization." Chemosensitization can be accomplished by combining a commercial fungicide wi...

Four acyl-hydrazones derived from 5-hydroxypicolinohydrazide and 4-hydroxybenzaldehyde (HL11), 2-fluoro-4-hydroxybenzaldehyde (HL12), 2,4-dihydroxybenzaldehyde (HL13) or 2-pyridinecarboxaldehyde (HL14) two hydrazones 2-hydrazino pyridine 4-dimethylaminobenzaldehyde (HL21) 4-diethylamino-2-hydroxybenzaldehyde (HL22) were synthesized their X-ray structures determined. Twelve rhenium(I) complexes ...

We studied the thermal decomposition of vanillin in a low-pressure pyrolysis microreactor by photoelectron photoion coincidence spectroscopy. The products were identified isomer-selectively mass-selected threshold spectra (ms-TPES) based on Franck–Condon simulations and reference spectra. Methyl loss homolytic C–O bond fission methoxy group is initial unimolecular step. primary intermediate, 2-...

Davood Nematollahi et al. have successfully electrosynthesised a series of benzofuran derivatives in the presence of nucleophile agents. Base on their experimental result, we analyzed the electron density of the intermediate during benzofuran derivatives synthesis and reached the same conclusions as that of Davood Nematollahi et al..Therefore, the method of electron density analysis is proven t...

Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (-)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (-)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (-)-bornesit...