Angiogenesis is a highly regulated event involving complex, dynamic interactions between microvascular endothelial cells and extracellular matrix (ECM) proteins. Alteration of ECM composition and architecture is a hallmark feature of wound clot and tumor stroma. We previously reported that during angiogenesis, endothelial cell responses to growth factors are modulated by the compositional and m...

conclusions stem cell therapies in wound care may lessen the morbidities associated with wound healing. an ideal method for the effective administration of stem cells for burn patients has not yet been elucidated. further comparison of the local and systemic effects in burn patients, associated with each route of stem cell delivery, needs to be performed. results application of cells to the bur...

AC loss generated in Superferric magnets composed of high temperature superconducting (HTS) coil windings and iron cores is one critical issues for rapid-cycling synchrotrons (RCSs) application. In this work, we carried out 3D FEM simulations HTS assemblies coupled with an core using the T-A ho...

Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling. Loss of the dermatan sulfate of decorin leads to an Ehlers-Danlos syndrome characterized by delayed wound healing. Decorin-null (Dcn(-/-)) mice display a phenotype similar to that of EDS patients. The fibrillar collagen phenotype of D...

Objective: This study was aimed to determine the biocompatibility of gelatin-alginate scaffolds with 3D bio-printer and the mice bone marrow mesenchymal stem cells (BMSCs), and the histocompatibility during skin wound healing. Methods: BMSCs was separated and cultured using pan-marrow attachment method and the third generation combined with gelatin-alginate was added to the 3D printer for the p...

Deep imaging within tissue (over 300 μm) at micrometer resolution has become possible with the advent of two-photon fluorescence microscopy (2PFM). The advantages of 2PFM have been used to interrogate endogenous and exogenous fluorophores in the skin. Herein, we employed the integrin (cell-adhesion proteins expressed by invading angiogenic blood vessels) targeting characteristics of a two-photo...

With the aging population of developed countries, diseases affluence become common. One consequences their complications are chronic wounds that affect more and people. Because healing is a lengthy process, its monitoring should be as simple possible, yet providing accurate reliable documentation. In this article, we present an image acquisition system wound surface reconstruction method using ...