Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is excessive neovascularization, which is orchestrated by the hypoxia-induced vascular endothelial growth factor (VEGF) stimulating endothelial cells and the integrin-mediated adhesive interactions of endothelial cells with extracellular mat...

BACKGROUND Early rehabilitation for acute stroke patients is widely recommended. We tested the hypothesis that clinical outcome of stroke patients who receive early rehabilitation managed by board-certificated physiatrists (BCP) is generally better than that provided by other medical specialties. METHODS Data of stroke patients who underwent early rehabilitation in 19 acute hospitals between ...

BACKGROUND Acute cholangitis is a life-threatening bacterial infection of the biliary tract. Main focus of this study was to create a useful risk prediction model that helps physicians to assign patients with acute cholangitis into different management groups. METHODS 981 cholangitis episodes from 810 patients were analysed retrospectively at a German tertiary center. RESULTS Out of eleven ...

AIMS To study the risk of childhood cancer in relation to parental occupation and related exposures. METHODS Self reported occupational data from mothers and fathers of 3838 children with cancer and 7629 control children were analysed. Odds ratios were calculated for 31 "occupational groups" by parent, diagnostic group (leukaemia, acute lymphoblastic leukaemia (ALL), central nervous system tu...

Abstract Efficient integration and visualization of heterogeneous biomedical information in a single view is key challenge. In this study, we present Arena3Dweb, the first, fully interactive dependency-free, web application which allows multilayered graphs 3D space. With users can integrate multiple networks along with their intra- inter-layer connections. For clearer more informative views, ch...

Heavy metal pollution may pose a significant threat to aquatic ecosystems. To assess heavy pollution, sediment samples were collected from Changwang and Wuyuan Rivers between June December 2019. An inductively coupled plasma mass spectrometer was used analyze the concentrations of As, Cd, Co, Cr, Cu, Mn, Ni, Pb, Zn. The results revealed that River had significantly high Cr (240.70 mg kg−1), Co ...

Apoptotic death of CD81 T cells can be induced by a population of inhibitory myeloid cells that are double positive for the CD11b and Gr-1 markers. These cells are responsible for the immunosuppression observed in pathologies as dissimilar as tumor growth and overwhelming infections, or after immunization with viruses. The appearance of a CD11b1/Gr-11 population of inhibitory macrophages (iMacs...

INTRODUCTION With the globalization of Chagas disease, unexperienced health care providers may have difficulties in identifying which patients should be examined for this condition. This study aimed to develop and validate a diagnostic clinical prediction model for chronic Chagas disease. METHODS This diagnostic cohort study included consecutive volunteers suspected to have chronic Chagas dis...

Measurements of the back scattering by bluntly-truncated tilted cylindrical shells in water reveal a dependence on the aspect angle which can be interpreted using geometrically described coupling mechanisms [S.F. Morse, P.L. Marston, and G. Kaduchak, J. Acoust. Soc. Am. 103, 785-794 (1998)]. By exciting a shell with a suitable acoustic pulse localized in time, the recorded backscattering respon...

Gene fusion represents a class of molecular aberrations in cancer and has been exploited for therapeutic purposes. In this paper we describe TumorFusions, a data portal that catalogues 20 731 gene fusions detected in 9966 well characterized cancer samples and 648 normal specimens from The Cancer Genome Atlas (TCGA). The portal spans 33 cancer types in TCGA. Fusion transcripts were identified vi...