We determined the role of carboxyl-terminal regulation of NOPR (nociceptin, orphanin FQ receptor) signaling and function. We mutated C-terminal serine and threonine residues and examined their role in NOPR trafficking, homologous desensitization, and arrestin-dependent MAPK signaling. The NOPR agonist, nociceptin, caused robust NOPR-YFP receptor internalization, peaking at 30 min. Mutation of s...

Pharmaceutical patents are anachronistic holdovers from an era in which Abstract modern economic understanding and tax tools were unavailable. Superior mechanisms lie somewhere between a first best pricing solution for the entire economy at one extreme and the current arrangements at the other. We discuss the economics of suggested alternatives and suggest that the intertemporal bounty is the b...

Objective: To estimate genetic, environmental, and rater contrast influences on parental reports of Activities, Social, School, and Total Competence scales of the Child Behavior Checklist (CBCL). Method: Parents of 492 twin pairs aged 8–12 years completed CBCLs. Genetic, shared and unique environmental, and rater bias effects were estimated for the Activities, Social, School, and Total Competen...

REPORTS OF SOCIETIES ROYAL SOCIETY OF MEDICINE: The Heart in Endocrine Disease ................ 360 ROYAL SOCIETY OF MEDICINE: Evaluation of Renal Clearances ................ 361 ROYAL STATISTICAL SOCIETY: International Statistics ......................... 362 MANCHESTER PAEDIATRIC CLUB .......... 362 SOCETY OF MEDICAL OFFICERS OF HEALTH: Accidents in the Home .... 362 LEEDS REGIONAL PSYCHIATRI...

Mice lacking the p27(Kip1) Cdk inhibitor (Cdkn1b) exhibit increased susceptibility to lymphomas from the Maloney murine leukemia virus (M-MuLV), and exhibit a high frequency of viral integrations at Xpcl1 (Kis2), a locus on the X-chromosome. Xpcl1 encodes miR-106a~363, a cluster of microRNAs that are expressed in response to adjacent retroviral integrations. We report the first large-scale prof...

The pressing demand to increase agricultural productivity amid the rapidly growing population has exponentially boosted fertilizers usage. Phosphate (Pi) runoff from induces eutrophication in water sources and severely affects its surrounding ecosystems. To cope with Pi accumulation problem, this study reported synthesis of an environmentally friendly magnetic adsorbent, namely Fe3O4/thiamine (...

INTRODUCTION ................................................................................... 343 I. 700 MHZ AUCTION .................................................................. 344 II. AUCTIONS AND THE PUBLIC INTEREST ................................. 351 A. Auctions as a Market Allocation Tool ..................................... 352 B. Auction Revenue as Compensation .................

* Corresponding author. Mailing address: Unidade de Protozoários Oportunistas/VIH e 16 outras Protozooses, Instituto de Higiene e Medicina Tropical, Rua da Junqueira, 96, 17 1349-008 Lisboa-Portugal. Phone: (351) 21-363-2600. Fax: (351)-21-363-2105. E-mail: 18 [email protected] 19 20 AC CE PT ED Copyright © 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rig...