Background: Rotavirus infection is the most important cause of infectious, severe and dehydrating diarrhea death in children aged 5 under continues to have a significant impact on child morbidity mortality our countries. The aim this study was retrospectively determine prevalence rotavirus adenovirus patients presenting with gastroenteritis symptoms distribution pathogens according gender, age ...

OBJECTIVE To determine clinical value of the use of the upper limit of individual normal range of intraocular pressure (IOP) in glaucoma diagnosing. MATERIAL AND METHODS The study enrolled 229 conditionally healthy participants (229 eyes) with no ocular complaints after a basic ophthalmic assessment. Ocular blood flow and IOP were measured with Ocular Blood Flow Analyzer (Paradigm Medical Ind...

Pituitary adenomas constitute 15-20% of intracranial neoplasms. Previously we reported that cyclin-dependent kinase 5 (CDK5) is upregulated in pituitary tumors associated with activating protein p35, and plays an essential role in pituitary adenomas progression. Here we explored the mechanisms of CDK5 signaling in prolactin pituitary adenomas. Our data indicate that p35 expression and CDK5 acti...

ABT-229 (8,9-anhydro-4"-deoxy-3'-N-desmethyl-3'-N-ethylerythromycin B-6,9-hemiacetal), a synthetic derivative of erythromycin (ERY) with no antibiotic activity, has been shown to bind to motilin receptors and stimulate contractile activity of the antrum and small intestine. The objective of this study was to determine the effect of ABT-229 on canine gastric emptying (GE) and contractile activit...

Background. Antiretroviral medications are key for prevention of mother-to-child transmission (PMTCT) of HIV, and transmission mitigation is affected by service delivery, adherence, and retention. Methods. We conducted a cluster-randomized controlled study in 26 facilities in Nyanza, Kenya, to determine the efficacy of SMS text messages on PMTCT outcomes. The relative risk and confidence interv...

A critical complication of factor VIII (FVIII) replacement therapy in Haemophilia A (HA) treatment is inhibitor development. Known genetic factors predisposing to inhibitor development include FVIII (F8) gene mutations, ethnicity, a family history of inhibitors and FVIII haplotype mismatch. The aim of this study was to characterize and correlate these genetic factors in a cohort of South Africa...

OBJECTIVES To compare the risk of epileptic seizures in adults during conservative management or following invasive treatment for a brain arteriovenous malformation (AVM). METHODS We used annual general practitioner follow-up, patient questionnaires, and medical records surveillance to quantify the 5-year risk of seizures and the chances of achieving 2-year seizure freedom for adults undergoi...

Dariush Ilghari, Kirsty L. Lightbody, Vaclav Veverka, Lorna C. Waters, Frederick W. Muskett, Philip S. Renshaw and Mark D. Carr Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, LE1 9HN, U.K. Running title: Solution structure of M. tuberculosis EsxG•EsxH complex * To whom correspondance should be addressed: Prof. Mark Carr, Tel. (+44) 116 229 7075; Fax (+4...