A new continuous retinoblastoma cell line (Rb 355-7) derived from a nonfamilial unilaterally-affected child was studied morphologically and with regard to HLA expression. The tumor was compared with two older and widely studied cell lines, the Y-79 and WERI-Rb1 strains. The Rb 355-7 line grew in tissue culture in clusters and chains. Its doubling time was calculated to be 4.4 days. In contrast ...

NeuroD1/BETA2 is a key regulator of pancreatic islet morphogenesis and insulin hormone gene transcription in islet beta cells. This factor also appears to be involved in neurogenic differentiation, because NeuroD1/BETA2 is able to induce premature differentiation of neuronal precursors and convert ectoderm into fully differentiated neurons upon ectopic expression in Xenopus embryos. We have ide...

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease of the apocrine gland-rich (AGR) regions with well characterized Th1/17 cytokine milieu. According to current literature data, keratinocytes are crucial drivers first pathogenic steps HS. However, possible role permeability barrier alteration, as KC activating event, has not been studied in detailed Our main focus was study n...

Corresponding author: Barry D. Bultz, PhD Professor and Head, Division of Psychosocial Oncology Professor, Department of Psychiatry Cumming School of Medicine, University of Calgary Director, Department of Psychosocial Oncology Tom Baker Cancer Centre, Calgary, Alberta, Canada Address: 2202 2nd Street SW, Calgary, Alberta, Canada, T2S-3C1 Tel: (403) 355-3207; Fax: (403) 355-3206 E-mail: bdbultz...

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