Myocardial infarction (MI) is commonly caused by atherosclerotic plaque rupture following excessive degradation of collagen fibers in the atherosclerotic lesion. We investigated whether interindividual variability in risk of MI was related to polymorphisms in the gene encoding matrix metalloproteinase (MMP)-1, a key fibrillar collagen-degrading enzyme. Several single nucleotide polymorphisms in...

BACKGROUND Gastric cancer is among the most common types of cancer, with high morbidity and mortality. MicroRNAs (miRNAs) play vital roles in the tumorigenesis and biology of gastric cancer. This study aimed to reveal the role of miR-340 in gastric cancer cell proliferation and apoptosis and to elucidate the potential mechanisms. MATERIAL AND METHODS Human gastric cancer cells SGC-7901 were use...

1.18.1 Beaconing 333 1.18.2 Route-Following 334 1.18.3 Path Integration 335 1.18.4 Map-Based Navigation 336 1.18.4.1 Small-Scale Maps (Centimeters to Meters) 336 1.18.4.2 Large-Scale Maps (Kilometers to Hundreds of Kilometers) 336 1.18.4.3 A Visual-Based Large-Scale Cognitive Map 337 1.18.4.4 A Sun-Calibrated Magnetic Compass 339 1.18.4.5 The Missing Links I – Navigation Behavior 340 1.18.4.5.1...

An increasing number of studies have demonstrated the important role of microRNAs (miRNAs) in modulating cancer progression and metastasis, but the mechanisms by which miRNAs regulate prostate cancer (PCa) tumorigenesis remain poorly understood. In the present study, we found that miR-340 may act as a tumor suppressor based on our finding that it was significantly downregulated in PCa tumor tis...

Surfactant protein D (SP-D) is an oligomeric C type lectin that promotes phagocytosis by binding to microbial surface carbohydrates. A 340-kDa glycoprotein (gp-340) has been shown to bind SP-D in the presence of calcium but does so independently of carbohydrate recognition. This protein exists both in a soluble form and in association with the membranes of alveolar macrophages. The primary stru...

Approved influenza vaccines based on the induction of antibodies to hemagglutinin are strain specific and Abstract cumbersome to manufacture. Several alternative vaccine strategies based on the induction of humoral responses against the external domain of the M2 protein, as well as cellular responses against nucleoprotein, have the potential to target multiple strains of influenza. A universal ...

OBJECTIVE To analyze clinical characteristics and prognostic factors of patients with malignancies combined with acute kidney injury (AKI), providing a basis for clinical AKI prevention and prognosis improvement. METHOD Hospitalized patients in the Central Hospital of Nephrology from January 2008 to December 2013 were screened by electronic medical record system; Statistical analysis formalig...