MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous silencers of target genes. Some tumor-suppressive miRNAs are known to be epigenetically silenced by promoter DNA methylation in cancer. In the present study, we aimed to identify miRNA genes that are silenced by DNA hypermethylation in hepatocellular carcinoma (HCC). We scree...

MicroRNA miR-335 has been reported to have both tumor suppressor and oncogenic activities. In order to determine possible tissue and cell type differences in response to miR-335, we examined the effect of miR-335 on cell expression of MT1-MMP, a proteinase commonly expressed in tumors and associated with cell proliferation and migration. miR-335 increased cell surface expression of MT1-MMP in f...

The aim of this study was to investigate the role of microRNA-335 (miR-335) in determining the treatment response and prognosis in adult acute myeloid leukemia (AML) patients receiving the cytarabine (Ara-C)-based chemotherapy.A total of 204 adult AML patients were collected. The miR-335 levels in serum and bone marrow samples from these patients were determined. All patients received Ara-C-bas...

Stanislaw R. Burzynski Burzynski Clinic, Houston U.S.A. __________________________________________________________________________________ *Correspondence: Stanislaw R. Burzynski, Burzynski Clinic, Houston USA; Tel: (713) 335-5697; Fax: (713) 335-5658; e-mail: [email protected]

Glioma is the most common malignant cancer affecting the central nerve system, with dismal prognosis. Differentiationinducing therapy is a novel strategy that has been preliminarily proved effective against malignant glioma. We have reported previously that activation of cAMP/protein kinase A (PKA) pathway is capable of inducing glioma cell differentiation, characterized by astrocyte-like shape...

To elucidate the transport system by which [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) is taken up into the liver, we investigated the uptake characteristics of Z-335 in isolated rat hepatocytes. In addition, we estimated the hepatic uptake of Z-335 in intact rats under steady-state conditions and compared it with the in vitro uptake clearance. Uptake of Z-335 is highly con...

Approved influenza vaccines based on the induction of antibodies to hemagglutinin are strain specific and Abstract cumbersome to manufacture. Several alternative vaccine strategies based on the induction of humoral responses against the external domain of the M2 protein, as well as cellular responses against nucleoprotein, have the potential to target multiple strains of influenza. A universal ...

The National All Schedules Prescription Electronic Reporting (NASPER) Act of 2005 is a law that provides for the establishment of a controlled substance monitoring program in each state, with communication between state programs. It amends the Public Health Service Act to require the United States (U.S.) Secretary of Health and Human Services to award 1-year grants to each state with an In the ...