three-dimensional objects. Douglas and colleagues’ work represents a third revolution in DNA nanotechnology. They have extended the DNA origami technique by showing how a DNA scaffold strand can form layers of helices arranged in a honeycomb lattice, thus providing a general-purpose, crystalline material from which three-dimensional objects can be constructed. In principle, any shape can be mad...

RNA-based therapeutics could represent a new avenue of cancer treatment. miRNA 331-3p (miR-331-3p) is implicated in prostate cancer (PCa) as a putative tumor suppressor, but its functional activity and synergy with other anti-tumor agents is largely unknown. We found miR-331-3p expression in PCa tumors was significantly decreased compared to non-malignant matched tissue. Analysis of publicly av...

Aberrant expression of microRNAs (miRNAs) is involved in the development and progression of various types of cancers. In this study, we investigated the role of miR-331-3p in cell proliferation and the expression of keratinocyte differentiation markers of uterine cervical cancer cells. Moreover, we evaluated whether neuropilin 2 (NRP2) are putative target molecules that regulate the human papil...

Several quinones have been found to be effective in the treatment of some forms of cancer; however, their cumulative heart toxicity limits their use. The cannabinoid quinone HU-331 [3S,4R-p-benzoquinone-3-hydroxy-2-p-mentha-(1,8)-dien-3-yl-5-pentyl] is highly effective against tumor xenografts in nude mice. We report now a comparison of the anticancer activity of HU-331 and its cardiotoxicity w...

Recent findings on the inhibition of angiogenesis and vascular endothelial cell proliferation by anthracycline antibiotics, which contain a quinone moiety, make this type of compound a very promising lead in cancer research/therapy. We have reported that a new cannabinoid anticancer quinone, cannabidiol hydroxyquinone (HU-331), is highly effective against tumor xenografts in nude mice. For eval...

Abstract Aim Drives towards ambulatory management in emergency surgery have resulted increased availability of urgent imaging to expedite decision making. This review CT usage aimed assess frequency surgical pathology identified, and subsequent management. Methods All acute general referrals an established clinic between 01/01/2021 22/07/2022 were included. Information regarding presentation, i...

The aim of this paper is to discuss what sort of baryon-number violating process arise on the supersymmetric versions of the model based on the gauge group SU(3)C ⊗SU(3)L⊗U(1)N . We discuss the mechanism of baryon number violation which induces proton decay, and derive bounds on the relevant couplings. [email protected]

Cannabidiol, the major nonpsychotropic phytocannabinoid, has been recently demonstrated to induce apoptosis in primary lymphocytes via an oxidative stress-dependent mechanism. Cannabidiol can be converted by microsomal enzymes to the hydroxyquinone metabolite HU-331 that forms adducts with glutathione. The present study tested the hypothesis that HU-331 could cause apoptosis via the depletion o...