Activation of the c-Jun N-terminal kinase (JNK) by proinflammatory cytokines inhibits insulin signaling, at least in part, by stimulating phosphorylation of rat/mouse insulin receptor substrate 1 (Irs1) at Ser(307) (Ser(312) in human IRS1). Here we show that JNK mediated feedback inhibition of the insulin signal in mouse embryo fibroblasts, 3T3-L1 adipocytes, and 32D(IR) cells. Insulin stimulat...

Medical History / Volume 60 / Issue 03 / July 2016, pp 301 307 DOI: 10.1017/mdh.2016.24, Published online: 13 June 2016 Link to this article: http://journals.cambridge.org/abstract_S0025727316000247 How to cite this article: Katja Guenther and Volker Hess (2016). Soul Catchers: The Material Culture of the Mind Sciences. Medical History, 60, pp 301-307 doi:10.1017/mdh.2016.24 Request Permissions...

The CREB-specific coactivator TORC2 (also known as CRTC2) upregulates gluconeogenic gene expression in the liver. Salt-inducible kinase (SIK) family enzymes inactivate TORC2 through phosphorylation and localize it in the cytoplasm. Ser(171) and Ser(275) were found to be phosphorylated in pancreatic beta-cells. Calcineurin (Cn) is proposed as the Ser(275) phosphatase, because its inhibitor cyclo...

DYNAMIC SYSTEMS THEORIES 258 Intellectual Heritage: Developmental Process 259 Lessons from Embryology: Form from a Formless Egg 260 The Mountain Stream Metaphor 263 Epigenesis in Developmental Psychobiology 263 Contextual and Ecological Theorists 266 An Introduction to Dynamics Systems Thinking 271 Development from a Dynamic Systems Perspective 276 Bimanual Coordination 297 What Is Skill? 298 S...

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