Sources of Compounds Tested-Thiamine hydrochloride (Merck, U.S.P. grade), 0-acetylthiamine hydrochloride and oxythiamine dihydrochloride (California Foundation for Biochemical Research), pyrithiamine hydrobromide and 4-amino-5 aminomethyl-a-methyl pyrimidine dihydrochloride (Nutritional Biochemicals Corporation) were all used without further purification. For determination of pK, values, the 4-...

BACKGROUND Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities. RESULTS 4-Methyl-2-phenylthiazole-5-carbohydrazide (2) was used as a synthon to prepare 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide (3) and 2-(2-(4-methyl-2-phenyl...

> introduction: escherichia coli is one of the important pathogens in human with global importance. because of the necessity for identification and the use of novel antibacterial compounds against e. coli , in this present study we focused on the antibacterial effects of synthesized thiazole, imidazole and tetrahydropyridine derivatives on e. coli . methods : for evaluation of antibacterial eff...

Xanthones and benzothiazoles are important classes of heterocyclic compounds with versatile biological activities. Herein, we describe a straightforward scalable synthesis 5-chloro-6-oxo-6H-xantheno[4,3-d]thiazole-2-carbonitrile, thiazole-fused xanthone, via six-step approach, using Appel’s salt for the thiazole ring. The xanthone was fully characterized employing 1H 13C NMR spectra, direct lon...

Purpose: In this study, we have focused on antibacterial effect of newly synthesized thiazole, imidazole, and tetrahydropyrimidine derivatives in Iran on listeria monocytogenes. Materials and Methods: For evaluation of antibacterial effect, the disk diffusion method was applied to measure the growth inhibition zone diameter and broth micro dilution was performed to determine the minimum inhibit...

It has now been firmly established by several groups of workers (1-10) that in yeast thiamine is enzymatically synthesized from pyrimidine pyrophosphate and thiazole monophosphate. However, there is little information about the biosynthetic pathways of pyrimidine and thiazole themselves. Thiamine was found as the first natural com pound containing a thiazole ring. Recently, the presence of the ...

Detailed structural and noncovalent interactions in two thiazole derivatives (N-(4-Bromophenyl)-2-(methylthio)thiazole-5-carboxamide Ethyl-5-((4-bromophenyl)carbamoyl)thiazole-4-carboxylate) are investigated by single crystal X-ray diffraction study computational approaches. The structure investigation revealed that various like C-H…O, N-H…O, N-H…N hydrogen bonds Br…Br involved constructing rin...

An alternative approach toward the simple and robust synthesis of highly substituted peptidic thiazole derivatives using Ugi-multicomponent reaction (U-MCR) is described. Thus, we introduced the enantiopure (R)-2-methyl-2-isocyano-3-(tritylthio)propanoate as a novel class of isocyanide in MCR. This bifunctional isocyanide was found to undergo mild cyclodehydration to afford thiazole containing ...

The synthesis and biological evaluation of 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against MCF7 breast cancer cell lines is reported. The design of the new compounds has been guided considering (3R)-6,7-bis(hydroxymethyl)-5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole as the lead compound due to its good performance against MCF7 breast cancer cell lines (IC(50)...

The first study on the reaction of C(+)-C-Se(-) 1,3-dipoles with electron-deficient alkenes and alkyne is reported. 2-Arylselenocarbamoylthiazolium inner salts, the unique thiazole carbene-derived C(+)-C-Se(-) 1,3-dipoles, reacted efficiently with methoxycarbonylallenes or dimethyl acetylenedicarboxylate to produce dihydroselenophenes or selenopheno[2,3-b]pyrazines, respectively, in high yields...