A new 2,3-disubstituted 1,2-dihydroquinazolin-4(3H)-one derivative namely 2-hydroxy-2-ethyl-(3-carboxylideneamino)-3-(2-(4-methyl-phenyl))-1,2-dihydroquinazolin-4(3H)-one (HECMDQ) is synthesized employing a modified method in higher yield and is complexed with Co(II), Ni(II), Cu(II) and Zn(II) metal ions in order to study its coordinating behavior. All the complexes were characterized by variou...

Cobalamin-dependant cytosolic enzyme methionine synthase (MetS) catalyses the transfer of a methyl group from the methyltetrahydrofolate (MTHF) to homocysteine (Hcy) to produce methionine and tetrahydrofolate (THF). MetS is over-expressed in the cytosol of certain breast and prostate tumour cells. Methionine used as a source of one carbon atom for the building of the DNA of the tumour cells, st...

A new efficient method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones and spiroquinazolinones via a condensation reaction of aldehydes and ketones with anthranilamide in the presence of nano Fe3O4@SiO2-SO3H as catalyst in ethanol has been described. The reactions are completed in short times, and the corresponding dihydroquinazolinones are produced with high yields. The present procedure...

In vitro anti-tubercular activity of a series 15 novel 2,3-dihydroquinazolin-4(1H)-one analogues were evaluated against Mycobacterium tuberculosis H37Ra (ATCC 25177 strain). Among the series, seven compounds showed moderate to good anti-TB with minimum inhibitory concentration (MIC) values ranging from 25.0–12.5 ?g/mL. Further, in silico experiments carried out identify probable ligand-protein ...