The electrochemical reduction of pyrazine (pz) on a silver electrode from a 1.0 M KBr solution has been investigated by surface enhanced Raman scattering (SERS). New bands from products of reduced pyrazine were observed at potentials more negative than [900 mV (vs. SCE). The main product is believed to be the 1,4-dihydropyrazine cation (DHPz`). The reduction is not completly reversible. It is c...

Using methanesulfonic acid as a catalyst, a series of cyclododeceno[b]indene derivatives were synthesized by the cyclization of alpha-benzylcyclododecanones, which were prepared by the reactions of cyclododecanones with a variety of substituted benzyl chlorides or bromides using NaH as a base. Their structures were confirmed by mp, IR spectra, 1H-NMR, 13C-NMR, MS, and x-ray diffraction. The pre...

Aqueous solutions of 5-aminolevulinic acid (ALA) prepared for intravesical instillation in the framework of a clinical study on the fluorescence diagnosis of urothelial bladder cancer were found to be unstable. This chemical instability of ALA was studied in aqueous solution of 37 degrees C as a function of concentration, pH and reaction time. Our investigations showed that the reaction of ALA ...

Pyrazines and substituted pyrazines undergo addition of boron reagents having B-B, Si-B, and H-B bonds under transition-metal-free conditions, leading to high-yield synthesis of N-borylated 1,4-dihydropyrazines and 1,2,3,4-tetrahydropyrazine.

Dihydropyrazines (DHPs), which break DNA strands and exhibit several other biological activities by generating radical species and high chemical reactivity as shown in our previous papers, reacted with thiourea to give tetraazaindene derivatives which were new compounds, even though thiourea is scavenges radicals. These derivatives can break DNA strands and inhibit the growth of Escherichia col...