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The tp53 gene is found to be mutated in 50% of all the cancers. The p53 protein, a product of tp53 gene, is a multi-domain protein. It consists of a core DNA binding domain (DBD) which is responsible for its binding and transcription of downstream target genes. The mutations in p53 protein are responsible for creating cancerous conditions and are found to be occurring at a high frequency in the...

The title salt, triphenyl(P,P,P-triphenylphosphineimidato-kN)-phosphorus(1+) 1,3,5,7-tetrathia(1,5-SIV)-2,4,6,8,9-pentaazabicyclo[3.3.1]nona-1,4,6,7-tetraene(1-), CAS [48236-06-2], prepared by the literature method, is found by crystallography to be a 1:1 CH3CN solvate. Disorder exists for the N atoms of the anion. A VT crystal structure study was conducted at 100 K, 120 K, 140 K, 172 K, 200 K,...

N. Guskos, T. Bodziony, A. Biedunkiewicz and K. Aidinis Institute of Physics, Szczecin University of Technology al. Piastów 17, 70-310 Szczecin, Poland Solid State Section, Department of Physics, University of Athens Panepistimiopolis, 15 784, Greece Institute of Material Engineering, Szczecin University of Technology al. Piastów 17, 70-310 Szczecin, Poland Applied Physics Section, Department o...

aggregation of pharmaceutical proteins reduces the efficiency and increases the cost of production. it can also lead to the reduced efficacy of drug or cause side effects on the patient’s body. investigating how to create them plays an important role to find agents that prevents the aggregation. this study was allocated for understanding the mechanism of formation of the reteplase protein using...

+*McAllister, D (A-American Orthopaedic Society for Sports Medicine (AOSSM) First Time Investigator Award); *Markolf, K; *Oakes, D; *McWilliams, J; *Young, C +*UCLA Medical Center Department of Orthopaedic Surgery, Los Angeles, CA 90095-6902. Department of Orthopaedic Surgery UCLA Center for Health Sciences, Box 956902, Los Angeles, CA 90095-6902, 310-206-5250, Fax: 310-825-1311, DMcAllister@Me...