Coronary heart disease secondary to atherosclerosis is still the leading cause of death in the US. Animal models used for elucidating the pathogenesis of this disease primarily involve rabbits and pigs. Previous studies from this laboratory have demonstrated intraperitoneal injections of poloxamer 407 (P-407) in both male and female mice will lead to hyperlipidemia and atherosclerosis, suggesti...

the present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (pa) that can be used for the preparation of immediate release pellets formulation. two commercially available grades poloxamer 188 (p 188) and poloxamer 407 (p 407) were selected, and solid dispersions (sds) conta...

PreDREM is a database of DNA regulatory motifs and motifs modules predicted from DNase I hypersensitive sites in 349 human cell and tissue samples. It contains 845-1325 predicted motifs in each sample, which result in a total of 2684 non-redundant motifs. In comparison with seven large collections of known motifs, more than 84% of the 2684 predicted motifs are similar to the known motifs, and 5...

PAGE I. Precipitating antisera built up in pigeons . . . . . . . . . . . . . . . . . . . . . . . . . Object. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Technique of production . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . thod . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Choice of m...

We studied the antiadhesive effect of Poloxamer 407 (P407), together with modifications in the antimicrobial susceptibility of residual adherent staphylococci. Bacterial adherence was markedly inhibited (77% to more than 99.9%) whether polymethylmethacrylate was exposed to P407 before or during the adherence assay. Furthermore, residual adherent staphylococci appeared to be more susceptible to ...

deadline: April 15, 2001 For information, please contact Ms. Rachelle Anderson: tel 780 407-6576; fax 780407-6672; [email protected]

agnosed children and adults, respectively, were: 13 and 15 times greater for acute respiratory infection; 6 and 9 times greater for otitis media; 6 and 8 times greater for asthma; 6 and 12 times greater for upper respiratory infection; 5 and 8 times greater for conjunctivitis; 5 times greater (both children and adults) for chronic obstructive pulmonary disease/allied conditions; 5 and 8 times g...

A Boolean circuit C on n inputs x1, . . . , xn is a directed acyclic graph (DAG) with n nodes of in-degree 0 (the inputs x1, . . . , xn), one node of out-degree 0 (the output), and every node of the graph except the input nodes is labeled by AND, OR, or NOT; it has in-degree 2 (for AND and OR), or 1 (for NOT). The Boolean circuit C computes a Boolean function f(x1, . . . , xn) in the obvious wa...

The lack of readily available experimental systems has limited knowledge pertaining to the development of Salmonella-induced gastroenteritis and diarrheal disease in humans. We used a novel low-shear stress cell culture system developed at the National Aeronautics and Space Administration in conjunction with cultivation of three-dimensional (3-D) aggregates of human intestinal tissue to study t...