........................................................................................................................................................................... 198 Introduction ...................................................................................................................................................................... 199 Material and Methods ...................

Objective: Deregulation of the cell cycle and apoptosis mechanisms in normal cells causes many problems, including cancer. In this study, a genome-wide expression analysis of cell cycleand apoptosis-related genes in corticosteroid-, vincristine-, and melphalan-resistant U-266 multiple myeloma cell lines was conducted. Materials and Methods: Resistant U-266 sublines were induced by application o...

Human indigenous cutaneous leishmaniasis caused by Leishmania donovani complex is endemic in Sri Lanka. We performed an entomological survey to determine the distribution of probable vector species. Sand flies were collected in districts in the dry zone, in the wet zone highlands, and in the wet zone coastal belt of Sri Lanka using CDC light traps, sticky traps and cattle-baited net traps durin...

Antimicrobial resistance (AMR) is a global public health threat. Quality data on AMR are needed to tackle the rise of multidrug-resistant clones. These rare in low-income countries, especially sub-Saharan Africa. In this study, we investigated extended-spectrum β-lactamase–producing (ESBL) Enterobacteriaceae Bangui, Central African Republic. We collected 278 fecal samples from 0–5-year-old chil...

Susceptibility to type 1 diabetes (T1D) is strongly associated with MHC class II molecules, particularly HLA-DQ8 (DQ8: DQA1*03:01/DQB1*03:02). Monitoring T1D-specific T cell responses to DQ8-restricted epitopes may be key to understanding the immunopathology of the disease. In this study, we examined DQ8-restricted T cell responses to glutamic acid decarboxylase 65 (GAD65) using DQ8 tetramers. ...

Cell disruption in a novel 266 kHz system (0.6 ml) that has batch and flow-through capabilities was compared with that achieved with a 20 kHz (2.4 ml) generator. Batch suspensions of Saccharomyces cerevisiae were exposed to cavitation for times up to 5 min. Protein release (an assay of cell disruption) was measured using the Lowry method. The rate of protein release was similar for both systems...

The S-D bond dissociation dynamics of thiophenol-d1 (C6H5SD) pumped at 266, 243, and 224 nm are examined using the velocity map ion imaging technique. At both 266 and 243 nm, distinct peaks associated with X and A states of the phenylthiyl radical (C6H5S*) are observed in the D+ image at high and low kinetic energy regions, respectively. The partitioning of the available energy into the vibrati...