Mammalian mitochondrial DNA (mtDNA) is inherited principally down the maternal line, but the mechanisms involved are not fully understood. Females harboring a mixture of mutant and wild-type mtDNA (heteroplasmy) transmit a varying proportion of mutant mtDNA to their offspring. In humans with mtDNA disorders, the proportion of mutated mtDNA inherited from the mother correlates with disease sever...

1. Abstract 2. Introduction 3. Age-associated alterations in T cell function 4. T cell subsets 4.1. Other subset alterations: TH1 vs. TH2, Rhodamine 123 vs. R123, CD8 CD122 5. Thymus 5.1.Involution 5.2. Thymic productivity 6. Lifespan and homeostasis of T cell populations 6.1. Replicative senescence and sensitivity to apoptosis 7. T cell activation 7.1. TCR signaling 7.2. Costimulation 8. Influ...

It has been explained previously how using large dimensional signal-subspaces can reduce/eliminate bias in the estimated fMRI response (Burock and Dale [2000]: Hum Brain Mapp 11:249-260). It has also been explained how one can project this less biased estimate onto a one-dimensional subspace of interest (Burock and Dale [2000]: Hum Brain Mapp 11:249-260). In cases where there are multiple, corr...

Tears contain many different proteins which can act as endogenous fluorescence biomarkers. This biological fluid is not used in clinical practice yet. The aim of this work is an experimental analysis of final fluorescence intensity of tear ́s proteins from right and left eye of healthy subjects by synchronous fluorescence fingerprint. Tears of the healthy subjects exhibited the final protein flu...

This study examines the reliability of age estimation utilizing the Greulich and Pyle atlas in relation to a modern Scottish population. A total of 406 left-hand/wrist radiographs (157 females and 249 males) were age-assessed using the Greulich and Pyle atlas. Analysis showed that there was a strong correlation between chronological age and estimated age (females R(2) = 0.939, males R(2) = 0.94...

OBJECTIVES Partial atrioventricular septal defect (pAVSD) is routinely repaired with a low mortality. However, limited data are available on the long-term follow-up of these patients. The current study was designed to determine long-term survival and morbidity of a large cohort of patients operated on at a single institution. METHODS From 1975 to 2012, 249 consecutive patients underwent pAVSD...