In this study, the authors explored the use of positive, negative, and avoiding humor in 2 types of situations by individuals in romantic relationships. Participants (N = 154) rated their frequency of humor use in either a typical conflict scenario with their partner or a typical pleasant event. Participants also indicated their overall degree of romantic relationship satisfaction. Hierarchical...

So far, the optimization methods under consideration were presented for the continuous time case. This lecture describes a technique which allows one to apply the continuous time algorithms of H2 optimization, H-Infinity optimization, and Hankel optimal model reduction to discrete time systems. The technique is based on applying the familiar “Tustin” (or “bilinear”) CT to DT transformation. Whi...

In several recent studies, saccadic eye movements were found to be influenced by concurrent reaching movements. The authors investigated whether that influence originates in limb kinematic or kinetic signals. To dissociate those 2 possibilities, the authors required participants (N = 6) to generate pointing movements with a mass that either resisted or assisted limb motion. With practice, parti...

Introdução: O modelo brasileiro de assistência farmacêutica para acesso universal à terapia antirretroviral (ARV) é referência em todo o mundo. No entanto, garantir apenas a aquisição desses medicamentos não repercuti, obrigatoriamente, desfechos favoráveis as pessoas que vivem com HIV/AIDS (PVHIV/AIDS), há necessidade monitorar sua farmacoterapia, sabidamente complexa e, muitas vezes, leva uma...

Amino acid (aa) substitutions at position 245 of HIV-1 reverse transcriptase (RT) have been described to be associated to the presence of human leukocyte antigen (HLA)–B*5701 allele in the host, in particular in subtype B infection. Preliminary data show HLA–B*5701 prevalence of around 6.5% in Serbian population. In this study, we investigated the prevalence of RT codon 245 substitutions among ...

BACKGROUND Abacavir hypersensitivity is strongly associated with the human leukocyte antigen (HLA)-B*5701 allele; however, the cost of routine high-resolution HLA typing before initiation of therapy remains prohibitive. We propose a simple approach to reduce B*5701-associated abacavir hypersensitivity based on the screening of human immunodeficiency virus (HIV) reverse transcriptase (RT) for a ...

1 Reconstructing Paleogenomes 245 1.1 Ancient DNA 245 1.1.1 The Nature of Ancient DNA 245 1.1.2 The Common Effects of DNA Damage 246 1.2 The Recovery and Sequencing of Ancient DNA 246 1.2.1 Ancient DNA Extraction 246 1.2.2 DNA Library Preparation 247 1.2.3 Capture-Based Target Enrichment 248 1.2.4 Quantification of aDNA and Sequencing 249 1.3 Assembly and Analysis of a Paleogenome 250 1.3.1 Ini...