نتایج جستجو برای: 23 dihydroquinazolin 4 1h ones
تعداد نتایج: 1554192 فیلتر نتایج به سال:
2-Dihydroquinazolin-4(1H)-thiones were prepared in up to excellent yields from 2-aminobenzothioamides and aldehydes. The reaction is carried out in water without the use of any catalyst or promoter. The sulfur-containing substrate can be obtained easily by thiation of the corresponding nitrile by solid sodium hydrosulfide.
A new efficient method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones and spiroquinazolinones via a condensation reaction of aldehydes and ketones with anthranilamide in the presence of nano Fe3O4@SiO2-SO3H as catalyst in ethanol has been described. The reactions are completed in short times, and the corresponding dihydroquinazolinones are produced with high yields. The present procedure...
The paper describes industrially scalable synthesis and single crystal studies of 3-cyclopropyl3,4-dihydroquinazolin-2(1H)-one 4, a versatile intermediate in the synthesis of number of biologically active compounds. The target compound has been characterized by LC-MS, 1H NMR and IR. The crystal structure analysis shows that the title compound crystallizes in monoclinic class under the space gro...
We herein describe the rapid synthesis of a diverse set of dihydroquinazolin-4-ones and quinazolin-4-ones, their biological evaluation as thyroid stimulating hormone receptor (TSHR) agonists, and SAR analysis. Among the compounds screened, 8b was 60-fold more potent than the hit compound 1a, which was identified from a high throughput screen of over 73,000 compounds.
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