The myalogenous leukemia call line K-562 with a Ph'+ chromosome, derived from a patient with chronic myalo ganous leukemia in terminal blashic crisis, is not a bone marrow-derived lymphoblastic call line, because the cells neither produce immunoglobulins nor possess complement receptors. Since it has been suspected that blasts found in some patients with chronic myelogenous leukemia in bIas tic...

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Toxoplasmosis is caused by the intracellular protozoan Toxoplasma gondii. It is anopportunistic zoonosis in warm-blooded animals and humans, with a worldwide distribution. Toxoplasma gondii dense granule protein 16 (TgGRA16) can modulate some functions in host cells and is considered a significant virulent factor of the parasite. The present study reports sequence variation in TgGRA16 gene amon...

This project was designed to characterize olfactory tissue-specific proteins previously identified with a library of monoclonal antibodies raised against frog olfactory cilia. First, we showed that our olfactory tissue-specific monoclonal antibodies all recognize different molecular forms of the same protein. We named this protein "olfactomedin". We then proceeded to purify olfactomedin and cha...

Mangrove forests in Kenya have traditionally been used as a source of building poles and firewood (1–3). About 70% of the population along the Kenyan coast depend on mangrove poles for house construction (4), and the recent boom in tourism in the area over the last few decades has led to an increasing demand for mangrove poles for construction of restaurants, hotels and holiday resorts (5). The...

2014 Recently we have developed a Couette viscosimeter for studying the shearing of colloidal crystals. We report here that with increasing shear rate the colloidal crystal melts (for 03C9crit) and above a critical shear rate, 03C9T0, Taylor instabilities develop. After stopping the shearing flow the suspension recrystallizes in a special texture which preserves the pattern of the Taylor rolls....

Compounds that induce the synthesis of cytoprotective phase II enzymes have shown promise as cancer chemopreventive agents. Although chemically diverse, phase II enzyme inducers are capable of participating in Michael reaction chemistry. We have synthesized a novel class of organosulfur compounds, termed oxathiolene oxides (OTEOs). Based on their chemical properties, we hypothesized that these ...

We study local search algorithms for metric instances of facility location problems: the uncapacitated facility location problem (UFL), as well as uncapacitated versions of the k-median, k-center and kmeans problems. All these problems admit natural local search heuristics: for example, in the UFL problem the natural moves are to open a new facility, close an existing facility, and to swap a cl...

Interferon (IFN)-gamma is a critical mediator of immunity to malaria. This study explored the relationship between polymorphisms in the promoter region of the gene encoding IFN-gamma receptor 1 (IFNGR1) and susceptibility to malaria in African children. Four polymorphisms were found in the region between -1400 and +100 nt of the translational start site by sequencing, and analysis of 562 nuclea...

A parallel programming library for molecular dynamics (MD) simulations is described and applied to the recently proposed split integration symplectic method (SISM) for MD simulation. The results show that for a system of 1024 linear chain molecules with an integration step of 4.5 fs parallel execution of SISM with the particle–particle interactions (PPIs) library on 32 computers gives efficienc...