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Artificial molecules that exhibit specific recognition of duplex DNA have attracted great interest because of their potential application in the manipulation of gene expression. Specific chemical reactions to the target base within the predetermined site would secure selective inhibition at either translation or transcription reactions. A more interesting application would be to alter the react...
Genome3D (http://www.genome3d.eu) is a collaborative resource that provides predicted domain annotations and structural models for key sequences. Since introducing Genome3D in a previous NAR paper, we have substantially extended and improved the resource. We have annotated representatives from Pfam families to improve coverage of diverse sequences and added a fast sequence search to the website...
To progress the development of deployable, lightweight infrastructure for relief and recovery efforts in the aftermath of natural and man-made disasters, this article develops a proof of concept for a smart mast that leverages the versatility of pantograph systems and advances in sensor, actuator, and informatics technologies. More specifically the article addresses key design criteria of trans...
Independent experimental and theoretical studies of the unfolding of barley chymotrypsin inhibitor 2 (CI2) are compared in an attempt to derive plausible three-dimensional structural models of the transition states. A very simple structure index is calculated along the sequence for the molecular dynamics-generated transition state models to facilitate comparison with the phi F values. The two a...
We report herein a case with dysmorphic features, polysyndactyly and psychomotor mental retardation, who had an apparently balanced de novo translocation between chromosomes 8 and 13 as well as a de novo insertion within chromosome 2 itself. This case is worth mentioning in the sense that it bears two de novo rearrangements with five breakpoints. The correlation between the possible disrupted g...
A new fault list reduction approach is proposed for use in the first stage of a two-stage bridge fault diagnosis procedure. Modified structural analysis and layout extraction procedures are performed to obtain a reduced realistic bridge fault list that can be used in the second stage, which employs diagnostic fault simulation. The fault list reduction approach can reduce the final candidate bri...
Article history: Received 26 August 2015 Received in revised form 6 April 2016 Accepted 6 April 2016 Available online xxxx Venture creation generates value in a variety of forms both for the entrepreneur him or herself and the venture's stakeholders. Recent research explores entrepreneurial action as a vehicle for personal transformation and development for the individual, especially as it pert...
Oligonucleotide models of ribosomal RNA domains are powerful tools to study the binding and molecular recognition of antibiotics that interfere with bacterial translation. Techniques such as selective chemical modification, fluorescence labeling and mutations are cumbersome for the whole ribosome but readily applicable to model RNAs, which are readily crystallized and often give rise to higher ...
The crystal structures of the title compounds, (3-aminOpyridiniUm),cU2cl6 and ( 3-aminopyridinium),Cu2Br6.H20, have been determined. The chloride dimer is monoclinic [a = 7.623 (1) A, b = 14.700 (2) A, c = 8.121 (1) A, j3 = 93.09 (1)O] and crystallizes in the space group PZ,/a, while the bromide dimer is monoclinic [a = 19.096 (5) A, 6 = 6.729 (1) A, c = 19.499 ( 5 ) A, /3 = 126.89 (1)O] and cr...
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