Inhibition of the growth of Lactobadlus casei with folic acid as the nutrilite is a general property of 2,4-diaminopyrimidines, 2-aminopyrimidines, and condensed systems containing these groupings (1). These compounds comprise a spectrum of inhibitors. At one end lie the simpler diaminopyrimidines which are competitive antagonists of folic acid (1, 2). The center may be represented by 2-aminopu...

BACKGROUND Pyrimethamine [2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine] is an antifolate drug used in anti-malarial chemotherapy. Pyrimidine and aminopyrimidine derivatives are biologically important compounds owing to their natural occurrence as components of nucleic acids. RESULTS In the crystal structures of two organic salts, namely pyrimethaminium benzenesulfonate monohydrate 1 and 2...

The discovery of ferrocene in 1951 sparked off a truly remarkable interdisciplinary research activity. Since then ferrocene and its derivatives have been immensely exploited for their potential applications in diverse fields such as homogeneous catalysis, organic synthesis, supramolecular chemistry, biosensors, medicinal chemistry and materials science. It is now well established that ferrocene...

The Escherichia coli thiM riboswitch forms specific contacts with its natural ligand, thiamine pyrophosphate (TPP or thiamine diphosphate), allowing it to generate not only nanomolar binding affinity, but also a high degree of discrimination against similar small molecules. A range of synthetic TPP analogues have been used to probe each of the riboswitch-ligand interactions. The results show th...

Electroanalytical methods enable determination of electroactive species in nonhomogeneous systems, as limiting currents are little affected by the presence of solid and colloidal particles. An example of such applications of electrochemical methods are studies of binding of toxic substances, such as pesticides, on slightly soluble polymers, such as lignin. To successfully apply polarographic me...