نتایج جستجو برای: 2 3 indolyl 45 di phynyl imidazoleidpi
تعداد نتایج: 3642027 فیلتر نتایج به سال:
A novel synthetic methodology for the synthesis of Bis(indolyl)methanes by using catalytic amount of ferric triflate was described Introduction Bis(indolyl)methanes consists two substituted indole units in the molecule. Bis indole derivatives are reported to exhibit a wide spectrum of pharmacological activities such as cytotoxic, antitumor antimicrobial [1] and antiactivities. [2] For the past ...
Methuosis is a form of nonapoptotic cell death characterized by an accumulation of macropinosome-derived vacuoles with eventual loss of membrane integrity. Small molecules inducing methuosis could offer significant advantages compared to more traditional anticancer drug therapies that typically rely on apoptosis. Herein we further define the effects of chemical substitutions at the 2- and 5-ind...
A series of indolyl acrylamide derivatives was synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Furfurylamine containing indolyl acrylamide derivative 5h exhibited the most potent DGAT inhibitory activity using microsomes prepared from rat liver. Further evaluation against human DGAT-1 and DGAT-2 identified indolyl acrylamide analogues as selective inhibitors against h...
ZnO nanorods have been prepared through chemical deposition of Zn(OAc)2.2H2O by employing different capping agents, (PEG, MW=2000 and PEG, MW=5000). The fabricated catalyst was characterized by scanning electron microscope (SEM) images and XRD pattern. The results show the one dimensional growth of ZnO nano-rods. The results show that capping agents can control the shape and growth of nano-size...
The study aimed to synthesize and evaluate the potential anti-inflammatory analgesic activities of rationally designed hybrid molecules imidazolone indole nuclei linked through a methylene bridge. Indolyl-imidazolone hybrids were synthesized in three simple steps starting from 2-phenyl-1 H -indole ( 1 ). In first step, compound was converted -indole-3-carbaldehyde 2 ) using standard conditions ...
The oxidation of β-(3-indolyl)propionic acid and γ-(3-indolyl)-n-butyric acid by peroxidase and Mn2+
A new and efficient method for the preparation of highly enantiomerically enriched α-aryl 2- or 3-indolyl-methanamines by rhodium-catalyzed asymmetric arylation of N-sulfonyl indolylimines with arylboronic acids using chiral bicyclo[3.3.0] diene was developed.
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