A sub-1V bandgap voltage reference (BGVR) in 0.16μm CMOS is presented that circumvents the trade-off between area and power consumption in conventional sub-1V BGVR topologies. This circuit can be used in systems to generate reference voltages locally, eliminating the conventional relatively large BGVR and its global reference voltage distribution interconnect. The active area is 0.0025mm; at 29...

We have isolated a variant of human immunodeficiency virus type 1 (HIV-1) which is highly infectious to fibroblastlike cells (BT cells) derived from human brain as well as CD4-positive T cells. This variant HIV-1, named HIV[GUN-1V], was obtained by infecting BT cells with a prototype HIV-1 isolate, named HIV[GUN-1WT], which is highly infectious to T cells but barely infectious to BT cells. HIV[...

RAF (Ras activating factor) kinases are important and attractive targets for cancer therapy. With the aim of discovering RAF inhibitors that bind to DFG-out inactive conformation created by the movement of Asp-Phe-Gly (DFG), we conducted structure-based drug design using the X-ray cocrystal structures of BRAF (v-raf murine sarcoma viral oncogene homolog B1), starting from bisarylurea derivative...

BACKGROUND AND OBJECTIVE Children with congenital heart disease (CHD) are at risk for developmental delay (DD). Changes in cognitive, language, and motor skills in early childhood have not been described. We report the results of a structured approach using longitudinal testing to identify problems and ensure early intervention in accordance with published guidelines. METHODS Bayley Scales of...

bachground: toxic plants are an important reason for poisoning. the responsible plants are variable in different geographic spots. some areas such as lorestan province have more variety in herbal plants because of geographic condition. because of high poisoning incidence with toxic plants and mushroom, we assessed the incidence of poisoning with mushroom and toxic plants (tattore and ricinus co...


 Prunus Arminica.L seeds of Hunza cultivar were defatted with chloroform, methanol mixture (2:1v/v) by ultrasonic assisted extraction technique. The lipase and phospholipase extracted, incubated at 400C pH 6 in citrate buffer for 1 hour. lipolytic activities enzymes measured different temperatures i,e 30-700C , 3-9 solvents n-heptane Di-isopropyl ether Cyclo hexane. 10 % emulsion lecithin...

introduction: due to dissimilarities in the availability of poisons in different areas and lack of enough control over the purchase and sale of some dangerous rodenticides, it is prudent to establish the distribution of rodenticide poisoning in each region. therefore, this study was performed to evaluate the demographic factors, types of poisons, duration of hospitalization and mortality of pat...

The bacterial factors responsible for the variation in invasive potential between different clones and serotypes of Streptococcus pneumoniae are largely unknown. Therefore, the isolation of rare serotype 1 carriage strains in Indigenous Australian communities provided a unique opportunity to compare the genomes of non-invasive and invasive isolates of the same serotype in order to identify such...