Angiotensin-converting enzyme (ACE) inhibitory activity was evaluated for the low-molecular-weight fraction (<3 kDa) obtained from milk fermentation by Bifidobacterium longum KACC91563. The ACE inhibitory activity in this fraction was 62.3%. The peptides generated from the <3 kDa fraction were identified by liquid chromatography-electrospray ionization quantitative time-of-flight mass spectrome...

In this paper we propose a methodology for developing representation formalisms for mathematical knowledge bases. We propose to equip knowledge bases with a hierarchy of logical systems that are linked by logic morphisms. These mappings relativize formulae and proofs and thus support translation of the knowledge to the various formats currently in use in automated deduction. On the other hand t...

The construction of stiiy accurate and B-stable multi-implicit Runge-Kutta methods for parallel implementation is discussed. A fth and a seventh order method is constructed and a promising numerical comparison with the eecient Radau5 code of E. Hairer and G. Wanner is conducted.

BCR-ABL1-specific tyrosine kinase inhibitors prolong the life of patients with chronic myeloid leukemia (CML) but cannot completely eradicate CML progenitors. The BH3 mimetic, ABT-263, targets prosurvival BCL2 family members, and has activity against CML progenitors. However, the inhibitory effect of ABT-263 on BCL-XL, which mediates platelet survival, produces dose-limiting thrombocytopenia. A...

PURPOSE To investigate the molecular mechanism underlying intrinsic resistance to ABT-199. EXPERIMENTAL DESIGN Western blots and real-time RT-PCR were used to determine levels of Mcl-1 after ABT-199 treatment alone or in combination with cytarabine or daunorubicin. Immunoprecipitation of Bim and Mcl-1 were used to determine the effect of ABT-199 treatment on their interactions with Bcl-2 fami...