Mefenamic acid (MFA), a carboxylic acid–containing nonsteroidal anti-inflammatory drug, is metabolized into the chemically-reactive MFA-1-O-acyl-glucuronide (MFA-1-O-G), MFA-acyl-adenylate (MFAAMP), and the MFA-S-acyl-coenzyme A (MFA-CoA), all of which are electrophilic and capable of acylating nucleophilic sites on biomolecules. In this study, we investigate the nonenzymatic ability of each MF...

Regulation of cystic fibrosis transmembrane conductance regulator (CFTR) mRNA levels is not well understood. Mouse Cftr mRNA shows strain-dependent expression differences that cannot be fully explained by variation at non-Cftr loci. Differences in tracheal and colonic expression appear to be due predominantly to elements linked to Cftr. Fifteen single nucleotide sequence variations were found w...

Z. G. Hu,1 M. Strassburg,1,2 N. Dietz,1 A. G. U. Perera,1,* A. Asghar,2 and I. T. Ferguson2,3 1Department of Physics and Astronomy, Georgia State University, Atlanta, Georgia 30303, USA 2School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA 3School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332,...

The Rheumatology Division in the Department of Internal Medicine at Shiraz University of Medical Sciences) (former Pahlavi University) (was established by Dr. Ali-Asghar Eghtedari in 1970. Drs. Mohammad Salami and Hadi Hedayati joined this division in 1973 and 1974, respectively. Since 1980, Dr. Akbar Rajaee has been in charge of this division. In 1986, the rheumatology subspeciality training p...

When Bruce Zetter called me late at night on January 14 with news of Judah Folkman’s passing, my shock and grief were almost as great as when I learned, 8 years earlier, of my own father’s sudden death. I suspect many people shared my reaction, especially fellow researchers in the field of tumor angiogenesis. After all, he was widely acknowledged to be the father of the field, and a doting one ...

tinere talente recrutate de profesorul Thoma Ionescu, a cărui intuiţie în alegerea colaboratorilor, viitorilor profesori de chirurgie, şefi de şcoală la rândul lor, nu a dat niciodată greş. Născut la 14 mai 1870 în oraşul Bârlad, acest fiu strălucit al pământului Moldovei, a reuşit prin calităţile sale înnăscute, dar mai ales printr-o muncă ordonată şi neobosită, să făurească o operă nepieritoa...