접수일:2008년 1월 17일, 승인일:2008년 3월 18일 책임저자:이 철, (570-749) 전북 익산시 신용동 344-2 원광대학교 의과대학 마취통증의학교실 Tel: 063-859-1560, Fax: 063-857-5472 E-mail: [email protected] 이 논문은 2007년도 원광대학교 교내 연구비 지원에 의해 연구되었음. Received January 17, 2008, Accepted March 18, 2008 Correspondence to: Cheol Lee Department of Anesthesiology and Pain Medicine, School of Medicine, Wonkwang University, 344-2, Sinyong-dong, Iksan 5...

OBJECT The surfactant, poloxamer 188 (P-188), has been found to protect against tissue injury in various experimental models. Its protective mechanism may involve the effects of the surfactant against oxidative stress and inflammation. The authors investigated the role of P- 188 in the reduction of tissue injury and macrophage response in a model of excitotoxic brain injury in the rat striatum....

BACKGROUND Reperfusion after prolonged coronary artery occlusion may be followed by additional myocardial necrosis persisting for hours to days. Potential mechanisms include neutrophil-mediated injury and compromised flow within the microcirculation of the reperfused myocardium. Poloxamer 188 is a nonionic surfactant with beneficial hemorheological and neutrophil-inhibitory properties. The purp...

Using x-ray scattering measurements we have quantitatively determined the effect of poloxamer 188 (P188), a polymer known to seal damaged membranes, on the structure of lipid monolayers. P188 selectively inserts into low lipid-density regions of the membrane and "corrals" lipid molecules to pack tightly, leading to unexpected Bragg peaks at low nominal lipid density and inducing lipid/poloxamer...

The controversy over abusive interrogations of prisoners during the war against terrorism spotlights the need for clear ethics norms requiring physicians and other clinicians to prevent the mistreatment of prisoners. Although policies and general descriptions pertaining to clinical oversight of interrogations in United States' war on terror prisons have come to light, there are few public recor...

Obesity is a critical health concern and although genetic factors may predispose an individual to become obese, changes in diet and lifestyle over the last few decades are likely to be significant contributors. Even so, it has been suggested that the causes of the current obesity crisis are not simply explained by changes in eating and exercise habits. Evidence suggests that the gut microbiota ...