Transforming growth factor-β1 (TGF-β1) and collagen type I (Col-1) serve a critical role in the development and progression of hypertrophic scarring (HS). The present study hypothesized that a post‑translational mechanism of microRNAs (miR) regulated the expression of TGF‑β1 and Col‑1 in HS fibroblasts (HSFBs). A collection of 20 HS tissues was compared with corresponding normal tissues from cl...

Increasing evidence has shown that microRNAs play critical roles in the initiation and progression of non-small cell lung cancer (NSCLC). miR-185 is deregulated in various cancers, whereas its functional mechanism in NSCLC is still unclear. Here, we confirmed that the expression of miR-185 was significantly down-regulated in NSCLC tissues and cell lines. miR-185 over-expression caused significa...

Samenvatting 185 Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185 Samenvatting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 186

The receptor for advanced-glycation end products (RAGE) is upregulated in various cancers and has been associated with tumor progression, but little is known about its expression and regulation by microRNAs (miRNAs) in esophageal squamous cell carcinoma (ESCC). Here, we describe miR-185, which represses RAGE expression, and investigate the biological role of miR-185 in ESCC. In this study, we f...

MicroRNAs (miRs) have been recognised as important regulators of malignant behaviour in different types of human cancer, including nasopharyngeal carcinoma (NPC). A previous study by our group revealed that miR-185-3p regulates the radioresistance of NPC cells. The present study aimed to investigate the effect of miR-185-3p on NPC invasion and metastasis. Human NPC CNE-2 and 5-8F cell lines wer...

1 Dr K Shilpa, MBBS,MD (DVL), Assistant Professor 2 Dr B Leelavathy, MBBS, MD(DVL), Professor and Head 3 Dr K Kavya, MD, Junior Resident 4 Dr DV Lakshmi, DVD, Junior Resident 5 Dr G Divya, MBBS,MD(DVL), Senior Resident Department of Dermatology, Venereology, Leprology, Bangalore Medical College and Research Institute, Bangalore. KR Market, Bengaluru-560002, Karnataka, India Corresponding author...

The main products of the 185 nm photolysis of neat liquid tetrahydropyran are pent-4en-l-ol (7) (0 = 0.40), 2-(5'-hydroxypentyl)tetrahydropyran (10) (0.21), valeraldehyde (6) (0.13), and pentan-l-ol (8) (0.08). These products are thought to be formed via the biradical '0(0112)40112, and/or through intramolecular (6, 7, 8) and intermolecular (10) photoreactions. In the case of 10, the probabilit...

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