نتایج جستجو برای: 177lu and 90y
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Neuroendocrine tumours (NETs) are very rare diseases characterised by a high degree of histological and clinical heterogeneity. They can be silent (even producing some hormones) or clinically evident as a result of local growth and/or hormonal production. The diagnostic and therapeutic approach to patients with NETs should be multidisciplinary. A medical oncologist should coordinate a group of ...
PURPOSE Extra domain B (ED-B) fibronectin is a specific tumor matrix marker for targeting angiogenesis in solid tumors. In this study, the radiotherapeutic potential of the directly radioiodinated divalent anti-ED-B antibody fragment, L19 small immunoprotein (L19-SIP; 75,000 Da), was compared with a pretargeting approach using the bispecific antibody AP39xm679 (bsMAb; 75,000 Da). EXPERIMENTAL...
177Lutetium (177Lu) is a member of the family of elements known as lanthanides or rare earths. Monoclonal antibody (MAb) CC49, a murine IgG1, which is reactive with the tumor-associated antigen, TAG-72, has been shown previously to react with a wide range of human carcinomas; CC49 reacts to a different epitope on the TAG-72 molecule than MAb B72.3 and has a higher binding affinity. We report he...
امروزه رادیوایمونوتراپی به عنوان یک روش نوین در درمان سلولهای سرطانی گسترده و میکرومتاستازها شناخته می شود. که در درمان متاستازهای سرطانی همانند متاستازهای استخوانی سرطان پروستات موثر واقع شده است. با توجه به همه مزایای رادیوایمونوتراپی در درمان اما این روش به علت نبو دانش کافی در زمینه طراحی درمان دچار محدودیت های عمده در عمل می باشد که علت عمده این محدودیت ها را می توان رزلوشن پایین سیستم های...
introduction: bone pain palliation therapy is a mandate in handling end-stage cancer patients. the development of new ligands with higher stability, better pharmacokinetics and lower unwanted tissue uptakes (liver and gi) is still ongoing. methods: in this work lu-177 labeled (3-amino-1-hydroxypropane-1,1-di-yl)-bis-(phosphonate) (177lu-pamidronate; 177lu-pam ), and (3-amino-1-hydroxybutane-1,1...
BACKGROUND CD37 is an internalizing B-cell antigen expressed on Non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia cells (CLL). The anti-CD37 monoclonal antibody HH1 was conjugated to the bifunctional chelator p-SCN-Bn-DOTA and labelled with the beta-particle emitting radionuclide 177Lu creating the radio-immunoconjugate (RIC) 177Lu-DOTA-HH1 (177Lu-HH1, trade name Betalutin). The prese...
BACKGROUND Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability of dosimetry-based MRT in clinical practice and research studies. The aim of this study was to assess the current practice of MRT and dosimetry across European countries. M...
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