introduction: in this research, [166ho]holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. finally a ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed.methods: 166ho-chitosan complex w...

background: skin cancer can be treated by various methods. electron radiotherapy has been a useful therapeutic modality in the treatment of skin cancers in areas which are difficult to cure by other methods. depth dose distribution of 166ho using varskin2 code is presented in this work. material and methods: depth dose distribution of 166ho was calculated, using varskin2 code by adding of 166ho...

in this study, production, quality control and biodistribution studies of 166ho-zoledronate have been presented as a possible bone marrow ablative agent. ho-166 chloride was produced by thermal neutron irradiation of natural 165ho(no3)3 samples. 166ho-zoledronate complex was prepared by adding the desired amount of zoledronate solution (0.2 ml, 150 mg/ml in 1 m naoh) to appropriate amount of th...

1 2 3 4 5 6 7 8 Quantitative and Functional Interrogation of Parent-of-Origin 9 Allelic Expression Biases in the Brain 10 11 Julio D. Perez, Nimrod D. Rubinstein, Daniel E. Fernandez, Stephen W. Santoro, 12 Leigh A. Needleman, Olivia Ho-Shing, John J Choi, Mariela Zirlinger, Shau-Kwaun 13 Chen, Jun S. Liu, Catherine Dulac* 14 Department of Molecular and Cellular Biology, Harvard University, How...

introduction: recently, due to the special characteristics of 166ho and chitosan, 166ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. this complex has been lately prepared with high radiochemical purity in our lab. the preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and normal tissues before...

AIM Radiolanthanide complexes with ligands bearing phosphonate groups have demonstrated their usefulness as bone seeking agents. Herein, we report on the synthesis of 153Sm and 166Ho complexes with 12- to 14-membered macrocycles containing different number of methylphosphonate pendant arms and their in vitro and in vivo evaluation in order to assess the effect of the cavity size and type of app...

Micelles derived from poly(ε-caprolactone) (PCL) poly(ethylene glycol)(PEG) diblock copolymers (HO-PCLn-b-PEG32-RX, R = -O(CH2)3S(CH2)2-; X = -CO2(-), -SO3(-), -NH3(+)) show corona charge selective degradation catalyzed by P. cepacia lipase isoforms.

bone is the third most common site of metastatic disease. bone pain is the major source of morbidity associated bone metastasis. bone-seeking radiopharma- ceuticals have been applied for many years. the ability to simultaneously treat multiple sites of disease with a more probable therapeutic effect in earlier phases of metastatic disease is one of the advantages of radiopharmaceuticals. 175yb ...