In the course of our chemical screening program for novel metabolites by LC-MS monitoring, we isolated a new aspochracin derivative, JBIR-15 (1), together with aspochracin, from the culture broth of a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. The structure of 1 was determined to be N-demethyl aspochracin at the alanyl residue on the basis of extensive NMR and MS analyses.

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I was very honored to receive the University of California, San Francisco, and the International Society of Pharmacometrics Lewis Sheiner lecturer award in May 2013. In the present perspective, I outline the main points of my lecture at the American Conference of Pharmacometrics (slides in Supplementary Material 1). I first emphasize the scientific contributions of Lewis Sheiner as a quantitati...

8-puzzle is typically solved by heuristic search. Real-time heuristic search usually gives better results when searching deeper. But sometimes deeper search leads to worse results than shallower which is a phenomenon called search pathology. In this paper we present the results of our investigation of the causes for pathology in 8-puzzle and some of its variations.

CuCl has been successfully immobilized on a novel diamide modified SBA-15, and proven to be an efficient heterogenized catalyst for the oxidative carbonylation of methanol to dimethylcarbonate.

We study a simple, general framework for search called bootstrap search, which is defined as global search using only a local search procedure along with some memory for learning intermediate subgoals. We present a simple algorithm for bootstrap search, and provide some initial theory on its performance. In our theoretical analysis, we develop a random digraph problem model and use it to make s...

In 2007, Alex Rodriguez signed a $275 million, ten-year contract with the New York Yankees, setting the record at the time for largest sports contract in history.1 Since then, he has faced many allegations of performance enhancing drug (―PED‖) use, one of which he confirmed through a public admission.2 Regardless of these allegations and admissions, Rodriguez continues to reap the benefits of h...

Over the last three decades, rapidly increasing interest has been shown, and a great growth has occurred in publications and new journals, related to assessing spiritual health and well-being. Most attention has been paid to university students (many of whom participate in research projects to gain credit points) and adults, many of whom have been in poor states of health. However, assessment o...