Toll-like receptors (TLRs) are major receptors that enable inflammatory cells to recognize invading microbial pathogens. MicroRNAs are small non-coding RNAs that play important regulatory roles in a variety of biological processes. In this study, we found that a microRNA, miR-147, was induced upon stimulation of multiple TLRs and functioned as a negative regulator of TLR-associated signaling ev...

A series of benzylamino inhibitors of acetylcholinesterase (AChE) have been designed based on a working hypothesis of the enzyme s active site. These compounds were tested for their inhibitory activities on AChE and potent inhibitors were further evaluated in terms of central selectivity. These studies led to a discovery of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4, 5-tetrahydro-1H-1-benzazep...

Rabeprazole sodium (RAB) is an anti-secretory agent which inhibits the enzyme H+/K+ ATPase, present in the stomach parietal cells. The aim of this work is to develop and validate a simple and fast ultraviolet spectrophotometric method (UV) for quantification of RAB in pharmaceutical formulation and compare it with a capillary electrophoresis (CE) one, previously validated. The UV technique was ...

Patients with hepatocellular carcinoma (HCC) experience poor prognosis and low survival rates. In this study, we explored the molecular mechanism of microRNA-147 (miR-147) in regulating human HCC. We firstly used quantitative RT-PCR (qRT-PCR) to compare the expression levels of miR-147 between 7 HCC and two normal liver cell lines, as well as 10 paired primary HCC tissues and their adjacent non...

This work represents an update of the previous evaluation nuclear data on A=147 nuclides (2009Ni02). The experimental from reaction and decay studies leading to following have been reviewed: 147I, 147Xe, 147Cs, 147Ba, 147La, 147Ce, 147Pr, 147Nd, 147Pm, 147Sm, 147Eu, 147Gd, 147Tb, 147Dy, 147Ho, 147Er, 147Tm. These are presented, together with adopted level schemes their properties. 147Pm nuclide...