background and objective: the management of apoptotic cell death has been considered as a putative therapeutic strategy for cancer treatment. in the present study we investigated the putative pro-apoptotic effect of allicin, the main garlic organosulfur component with repeatedly claimed chemopreventive potency, on the human adenocarcinoma cell line ht29 as an apoptosis resistant cell line, in v...

the cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. this study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder:andmicropowder. human hgf1-pi53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ml concentrations of the two bioactive...

background: pattern recognition receptors (prrs) are the main sensors of pathogen and danger signals in innate immunity of which toll like receptors (tlrs) are the most studied ones. the contribution of prrs in cerebral inflammation induced by microbial infection, tissue damage and cancer has not extensively been addressed so far. glioma is the most common tumor of the central nervous system an...

background: interfering with cell proliferation and survival is a critical role for antineoplastic drugs leading to cell death through induction of apoptosis. alternative treatments with herbal extracts offer insights into acute myeloid leukemia (aml) therapy. parthenolide (ptl), an extract from feverfew, induces apoptosis in primary human leukemia stem cells (lscs) and bulk leukemic cell popul...

Scorpion venom toxicity is of major concern due to its influence on human activities and public health. We investigated the in-vitro process of cell death caused by two Iranian scorpions Odontobuthus doriae and Bothutus salceyi venom on human cell lines. The aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...

a Department of Physics, Western Michigan University, Kalamazoo, MI 49008-5252, USA b National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI 48824-1321, USA c Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824-1321, USA d Joint Institute for Nuclear Astrophysics, Michigan State University, East Lansing, MI 48824-1321, USA e...

objective: nucleostemin (ns) is a recently identified gene that is expressed mainly in the nucleoli of neuronal, embryonic and mesenchymal stem cells which plays a role in their self renewal. over expression of this gene has been reported in several cancer cell lines tumoral tissues including gastric, hepatic and prostate cancer. in this study, we investigated the effects of suppression of this...

background : the development of chemoresistance represents a major obstacle in the successful treatment of cancers such as non-hodgkin’s lymphoma (nhl). with the recognition of important roles for both p53 and its more recently described paralog p73 in mediating the activity of anti-cancer drugs, there has been increasing recognition that cellular resistance to anthracyclines could and does a...

. 2004;291(11):1322. JAMA Linda H. Aiken et al. Relationship Between Patient Mortality and Nurses' Level of Education—Reply . 2004;291(11):1322. JAMA Ruth D. Corcoran et al. Relationship Between Patient Mortality and Nurses' Level of Education . 2004;291(11):1322. JAMA George R. Boggs. Relationship Between Patient Mortality and Nurses' Level of Education . 2004;291(11):1321. JAMA Carol Comeau e...

Owing to their location at the interface with external environment, stem cells of epidermis are particularly exposed environmental variations such as fluctuating temperature. However, little is known about how temperature affects epidermal cell metabolism and behavior. Here we demonstrate that cultured human (HESCs) respond a small drop in through thermos-sensitive TRP channels connected mTOR s...