Antigen-binding T and B lymphocytes were studied by combined autoradiography and immunofluorescence; mouse spleen lymphocytes binding the antigens, [(125)I]MSH or [(125)I]TIGAL, were incubated with rhodamine-labeled anti-Ig reagents or with a rhodamine-labeled IgG fraction of anti-theta serum. B cells were identified as Ig+ or theta-, T cells as Ig- or theta+. It was found that: (a) 20% (1-2 mo...

PURPOSE The purpose of this study is to compare the predicted value of the blood levels variations of CA 125 antigen and the imunohistochemical expression of CA 125, with imagistic criteria (The Response Evaluation Criteran in Solid Tumor--RECIST) regarding the survival estimation of female patients with relapsed ovarian carcinoma which undergo to second line chemotherapy. MATERIAL AND METHOD...

Objective: We aimed to evaluate the prognostic role of preoperative serum cancer antigen 125 (CA-125) in endometrioid endometrial for determining cut-off values clinicopathological factors.
 Study design: 161 patients were included study. The inclusion criteria histopathological confirmation and with CA-125 levels measured at most ten days before surgery. association between value variable...

INTRODUCTION Cancer antigen 125 (CA-125), known as a biomarker for women genital tract malignancies, could be also useful in detecting and monitoring endometriosis. The aim of this study was to evaluate CA-125 in serum and peritoneal fluid (PF) as an indicator of endometriosis. MATERIAL AND METHODS Fifty-six patients admitted to the First Department of Obstetrics and Gynaecology for diagnosti...

BACKGROUND The current study examined the clinical usefulness of YKL-40 in detection and prognosis of uterine cervical cancer. PATIENTS AND METHODS Serum levels of YKL-40, cancer antigen 125 (CA 125), carbohydrate antigen 19-9 (CA19-9), and squamous cell carcinoma (SCC) antigen were determined by enzyme-linked immunosorbent assay in women with benign gynecologic disease (n=24), cervical malig...

Background: Mesothelin is a tumor differentiation antigen; its binding to tumor-antigen CA-125 can lead to tumor metastasis. Results: Structures of the Fab from a therapeutic antibody MORAb-009 and its complex with an epitope-containing fragment of mesothelin are obtained. Conclusion: Overlapping binding sites for both CA-125 and MORAb-009 provides a basis for the antibody’s therapeutic effect....

Adenomyosis is an ectopic localization of endometrial tissue (glands and stroma) and autonomous development in the thickness of the uterine muscle. The prevalence of adenomyosis ranges from 5 and 70% [1] after hysterectomy according to the surgical indication [2], whatever them indications. Transvaginal ultrasound and magnetic resonance imaging exam (MRI) have currently an important place in th...