Introduction: Auger electron based radioimmunotherapy (RIT) using 111In-DOTA-trastuzumab (111In-DOTA-antiHer2) feasibility was studied in vitro on a HER2/neu positive cell line, SkBr3. Methods:111In-DOTA-antiHer2 was prepared according to the optimized conditions followed by quality control tests including radioch...

We present a comparative study of the structure and the dynamics of the most close packed surface of Ni, Cu, and Ag from near room temperature up to 0.9Tm , using molecular dynamics simulations and interaction potentials from the embedded atom method. Calculated shifts in the surface phonon frequencies, the broadening of their linewidths, and the variations in the mean square vibrational amplit...

UNLABELLED In most types of peptide receptor radionuclide therapy, the maximum activity dose that can be administered is limited by high and persistent renal retention of the radiolabeled peptides, which is, at least partly, mediated by the megalin receptor. Several agents that interfere with renal reabsorption of radiolabeled peptides have been identified (e.g., lysine, arginine, succinylated ...