نتایج جستجو برای: 10 mg kg l
تعداد نتایج: 1788795 فیلتر نتایج به سال:
Chronic inhibition of NO synthesis induces cardiac hypertrophy independent of systemic blood pressure (SBP) by increasing protein synthesis in vivo. We examined whether ACE inhibitors (ACEIs) enalapril and temocapril and angiotensin II type-I receptor antagonists (angiotensin receptor blockers [ARBs]) losartan and CS-866 can block cardiac hypertrophy and whether changes in activation of 70-kDa ...
BACKGROUND BPC 157 is a stable gastric pentadecapeptide recently implicated with a role in hemostasis. While NO is largely implicated in hemostatic mechanisms, in tail-amputation-models under heparin- and warfarin-administration, both the NO-synthase (NOS)-blocker, L-NAME (prothrombotic) and the NOS-substrate L-arginine (antithrombotic), were little investigated. Objective. To investigate the e...
Chronic inhibition of NO synthesis induces cardiac hypertrophy independent of systemic blood pressure (SBP) by increasing protein synthesis in vivo. We examined whether ACE inhibitors (ACEIs) enalapril and temocapril and angiotensin II type-I receptor antagonists (angiotensin receptor blockers [ARBs]) losartan and CS-866 can block cardiac hypertrophy and whether changes in activation of 70-kDa ...
Bile duct ligation (BDL) is an animal model used in cholestatic disease research. Both opioidergic and nitrergic systems are known to be involved in cholestasis. The aim of this study was to investigate the possible interaction between these two systems in BDL-induced memory formation and exploratory behaviors in mice. Male mice weighing 25-30 g were divided into nonoperated controls, sham-oper...
طبق مطالعات مختلف، مرفین دارای اثرات تعدیل کننده ایمنی می باشد. اما مکانیسم های دقیق این اثرات در cns تا حد زیادی ناشناخته است. در این مطالعه، پتانسیل بالقوه پیش تیمار مرفین در التهاب عصبی القاء شده با لیپوپلی ساکارید (lps) بررسی شد. بدین منظور، اثر سه دوز مرفین )10 و 7و 4 mg/kg) روی بیان سیتوکین های پیش التهابی tnf?,il-i? و cox-2 در هیپوکمپ rat، همچنین احتمال درگیری رسپتورهای اوپیوییدی mor و...
The objective of this study was to determine if the current dosage regimen for chloramphenicol CAP administered to children with severe malaria SM for presumptive treatment of concomitant bacterial meningitis achieves steady state plasma CAP concentrations within the reported therapeutic range of 10-25 mg/l. Fifteen children (11 male, 4 female) with a median age of 45 months (range: 10-108 mont...
L-Deprenyl (Selegeline) introduced for use in parkinson's disease, is implicated to show beneficial effects in epilepsy, alzheimer's disease, cognition, depression and other age related neurological diseases. In this study, we investigated the CNS effects of L-deprenyl with special reference to epilepsy, anxiety and cognition and memory in mice. L-deprenyl (10, 20 and 40 mg/kg) showed a signifi...
Recently, we demonstrated that the diffusible messenger molecule nitric oxide (NO) is involved in the hyperthermic response induced by morphine by using a nonselective nitric-oxide synthase inhibitor, N-nitro-L-arginine methyl ester. The present work extended these studies to include 7-nitroindazole (7-NI), an inhibitor specific for neuronal nitric-oxide synthase (nNOS), N(5)-(-iminoethyl)-L-or...
هدف مطالعه حاضر بررسی اثر مصرف توام کراتین با سرترالین بر بیان ترجیح مکان شرطی مورفین در موش سوری نر می باشد.در این مطالعه تجربی از موشهای سوری نر نژاد nmri در محدوده وزنی 20 الی 30 گرم استفاده شد.دراین آزمون متد 6 روزه متوالی؛ شامل سه مرحله جداگانه پیش شرطی، شرطی شدن و بعد شرطی شدن استفاده گردید.دربخش اول مطالعه، موشها بجای مورفین،جهت تعیین القاء رجحان مکان شرطی(cpp) یا تنفر مکان شرطی(cpa)،در ...
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