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Mast cells infiltrate kidneys of humans with crescentic glomerulonephritis (GN), and the degree of infiltrate correlates with outcome. However, a functional role for mast cells in the pathogenesis of GN remains speculative. GN was induced by intravenous administration of sheep anti-mouse glomerular basement membrane globulin. After 21 d, systemic immune responses and disease severity were analy...
از آنجا که متغیرهای زیادی بر میانگین غلظت سرمی تستوسترون در سگ ها تاثیرگذار هستند، مطالعه حاضر بر روی 6 قلاده سگ نر بالغ، سالم از نظر بالینی، از نژاد بومی و در محدوده سنی 2-5/1 سال انتخاب گردید. سپس در طول مدت مطالعه 1 سال (12 ماه)، هر 15 روز یک بار و در بازه زمانی 30/8 تا 30/11 قبل از ظهر، از ورید سفالیک خون گیری انجام شد. نمونه های خون سانتریفوژ گردیده و سرم ها تا بررسی نهایی، در منفی 20 درجه...
We investigated whether the stem cell that reconstitutes total erythropoiesis of a WBB6F1-W/Wv mouse differentiates into lymphoid lineage. The electrophoretic pattern of hemoglobin was used as a marker of the reconstitution; 3-phosphoglycerate kinase (PGK), an X chromosome-linked enzyme was used as a tool for estimating clonality. We injected 10(5) bone marrow cells of 5-FU treated C57BL/6-Pgk-...
Molecular dynamic simulation of water vapor interaction with blind pore of dead-end and saccate type
One of the varieties of pores, often found in natural or artificial building materials, are the so-called blind pores of dead-end or saccate type. Three-dimensional model of such kind of pore has been developed in this work. This model has been used for simulation of water vapor interaction with individual pore by molecular dynamics in combination with the diffusion equation method. Special inv...
Ataxias are neurological disorders associated with the degeneration of Purkinje cells (PCs). Homozygous weaver mice (wv/wv) have been proposed as a model for hereditary cerebellar ataxia because they present motor abnormalities and PC loss. To ascertain the physiopathology of the weaver condition, the development of the cerebellar cortex lobes was examined at postnatal day (P): P8, P20 and P90....
Normal mice (+/+) and homozygous weaver mutant mice (wv/wv) at 1 year of age were used for three-dimensional computer-aided reconstructions of the nucleus accumbens (NA) and neostriatum (ST) and for quantitative estimations of the total number of medium-sized neurons in the NA and ST, and for the total number of tyrosine hydroxylase (TH)-containing neurons in the ventral tegmental area (VTA) an...
The growth factor receptor Kit is involved in hematopoietic and nonhematopoietic development. Mice bearing Kit defects lack mast cells; however, strains bearing different Kit alleles exhibit diverse phenotypes. Herein, we investigated factors underlying differential sensitivity to IgG-mediated arthritis in 2 mast cell-deficient murine lines: KitWsh/Wsh, which develops robust arthritis, and KitW...
Previous studies have identified the cerebellar granule cell as a primary site of gene action in the weaver mutant mouse. The temporal expression of the weaver mutant granule cell phenotype has not been fully investigated. To identify early postnatal expression of the weaver mutant phenotype, we quantitated 4 parameters of cerebellar development in postnatal day 0, 2, 4, 6, and 8 +/+, wv/+, and...
1 Grupo Interdisciplinar de Sistemas Complicados (GISC), Departamento de Matemáticas, Universidad Carlos III de Madrid, Avda. de la Universidad 30, 28911 Leganés, Madrid, Spain. 2 Current Address: Institut für Theoretische Physik II, Heinrich-Heine-Universität, D-40225 Düsseldorf, Germany; e-mail: [email protected] 3 Department of Chemical Engineering, University of Amsterdam, Nieu...
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