discussion of the mode of action of ara-C does not include reference to its incorporation into RNA, a finding that may be of critical importance. Although IUdR and BUdR are indeed incorporated into cellular DNA, not only is it not true that FUdR is similarly incorporated, but also the references cited for this are incorrect (p. 86). Although Dr. Becker interprets Table X (p. 95) to show that a ...

Low-energy X-rays induce Auger cascades by photoelectric absorption in iodine present in the DNA of cells labeled with 5-iodo-2'-deoxyuridine (IUdR). This photoactivation therapy results in enhanced cellular sensitivity to radiation which reaches its maximum with 50 keV photons. Synchrotron core facilities are the only way to generate such monochromatic beams. However, these structures are not ...

A review has been presented of selected aspects of 5-iododeoxyunidine(IUDR) and of 6-azaunidine. Some of the basic problems which may be of pertinence to the successful use of IUDR clinically have been indicated. Although the role of IUDR as a chemotherapeutic agent in the treatment of neoplasms, either alone or in combi nation with other compounds or radiation, is still under investigation, it...

In view of the potential menace of a terrorism attack with smallpox virus, an intensive search of chemotherapeutic agents active against orthopoxviruses is underway. We comparatively studied the antiviral activity of cidofovir (CDV) and idoxuridine (IUdR) against two vaccinia virus (VV) strains, Bratislava and RIIPD, in cell cultures of chick embryo fibroblasts (CEF). The investigations were ca...

objective: in radiation treatment, the irradiation which is effective enough to control the tumors far exceeds normal-tissues tolerance. thus to avoid such unfavourable outcomes, some methods sensitizing the tumor cells to radiation are used. iododeoxyuridine (iudr) is a halogenated thymidine analogue that known to be effective as a radiosensitizer in human cancer therapy. improving the potenti...

Mice were injected intravenously and intraperitoneally with preparations of intestinal nucleoprotein, spleen nuclei, mouse thymus cells, or human kidney T cells whose DNA had been labeled with both [3H]thymidine (TdR) and [125I]-iododeoxyuridine (IUdR). Since free TdR is reutilized more efficiently than free IUdR produced by enzymic hydrolysis of the exogenous DNA, the ratio of [3H]TdR/[125I]IU...