Laws requiring mandatory Human Immunodeficiency Virus (HIV) testing for pregnant women have been contemplated by state legislatures since a ground breaking 1994 study showed that treating these women with antiretroviral drugs during pregnancy could decrease the chance of passing the disease to their children. Approximately 477 HIV-positive pregnant women participated in the AIDS Clinical Trial ...

PURPOSE OF REVIEW Long-acting injectable antiretroviral (ARV) formulations are being developed for the treatment and prevention of HIV infection. The purpose of this review is to summarize recent preclinical and clinical data on TMC278 (rilpivirine), a nonnucleoside reverse transcriptase inhibitor (NNRTI), that is being developed for both a treatment and prevention indication. RECENT FINDINGS...

Traditional approach to gearing up a cellular manufacturing system (CMS) is to consider only two dimensions, viz, “machine – component”. However, when the problem is addressed in a context of “product – part – machine” dimension, it provides a different perspective to the problem. The current study is an effort in this direction. A formulation of the CMS problem to a product oriented plant as w...

This prospective study, involving 76 pregnant women infected with HIV, paired with their 79 exposed infants, was carried out between May 1996 and October 2001, at the Reference Department for Pregnant Women Infected with HIV in Campo Grande, Mato Grosso do Sul. The mean age of the pregnant women was 24 years; 88% (67/76) apparently were infected due to sexual practices; 88% (67/76) were housewi...

The authors thank Ministerio de Ciencia Innovacion y Universidades and FEDER (Project RTI2018-095291-B-I00) the Generalitat Valenciana (PROMETEOII/2018/076) for financial support. JFC thanks MINECO a researcher formation grant (BES-2016-078079). MNG gratefully acknowledges Plan GenT (CDEIGENT/2018/027) postdoctoral grant. present work was partially supported by Grants-in-Aid Scientific Research...