From the Department of Pharmacology & *Medicine R. G. Kar Medical College, Kolkata 700 004 & **Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata 700 073 Correspondence to : Dr Indranil Banerjee, Demonstrator, Department of Pharmacology, R. G. Kar Medical College, Kolkata 700 004 A Study on Comparative Evaluation of Add-on Pralidoxime Therapy over Atropine in ...

Patients: 72 073 adults ≥ 40 years of age (mean age 65 y, 71% men) who had an incident diagnosis of gout. The control group comprised 358 342 adults without gout, matched for age, sex, date of study entry, and enrollment year. Exclusion criteria were history of septic arthritis, gout, osteoarthritis, rheumatoid arthritis, or other inflammatory rheumatic condition (seronegative spondyloarthropat...

Ultraviolet irradiation (UV) exposure constitutes the most relevant environmental hazard to human skin. UV-mediated cutaneous inflammation and direct DNA damage lead promotion of skin carcinogenesis. D-dopachrome tautomerase (D-DT), a functional homolog macrophage migration inhibitory factor (MIF), has similarities MIF. However, its role, unlike role MIF in photocarcinogenesis, is unknown. We t...

An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields excellent regioselectivity. Functionalizations indole products carried out affording highly valuable versatile compounds. The indolization protocol studied as a fundamental step prava...

In the process of searching for the recently described small anelloviruses 1 and 2 (SAVs) with the genomic DNA length of 2.2 or 2.6 kb in human sera, we isolated a novel virus with its genomic organization resembling those of torque teno virus (TTV) of 3.8-3.9 kb and torque teno mini virus (TTMV) of 2.8-2.9 kb. The entire genomic sequence of three isolates (MD1-032, MD1-073 and MD2-013), which ...

PURPOSE Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the epidermal growth factor family. The membrane-bound proHB-EGF is known to be a precursor of the soluble form of HB-EGF (sHB-EGF), which promotes cell proliferation and survival. While the functions of sHB-EGF have been extensively studied, it is not yet fully understood if proHB-EGF is also involved in...