Understanding drug glucuronidation in the dog, a preclinical animal, is important but currently poorly characterized at the level of individual enzymes. We have constructed cDNAs for the 10 dog UDP-glucuronosyltransferases of subfamily 1A (dUGT1As), expressed them in insect cells, and assayed their activity as well as the activity of the nine human UGT1As, toward 14 compounds. The goal was to f...

The prevalence of obesity is high in older persons and recent trends show a rapid increase in this prevalence. Results from observational and intervention studies (i.e. weight loss studies) show the strong negative impact of obesity on functional status in old age. There are different potential pathways through which obesity may lead to functional decline in older persons. Furthermore, the pres...

Department of Chemistry, University of Cal E-mail: [email protected]; p_yang@ Howard Hughes Medical Institute, Unive 94720, USA Chemical Sciences Division, Lawrence B California 94720, USA Joint Center for Articial Photosynthesi Laboratory, Berkeley, California 94720, USA Materials Sciences Division, Lawrence B California 94720, USA † Electronic supplementary information (E and structure...

The aim of the study was to assess the organoleptic differences of Clarias gariepinus smoked with two different energy sources, Anogeissus leiocarpus and Tamarindus indica with the help of a hedonic scale and to determine possible proximate composition difference between the smoked products. Smoking of the fishes was carried out for 4 hours using traditional smoking kiln, the chemical analysis ...

The problems of children and adolescents with epilepsy pose an important challenge for educational systems around the world. Epilepsy is the most common chronic neurological disease, which occurs in up to 1% of children and adolescents. The largest incidence of onset is from early childhood to adolescence, therefore, mostly the emotional, cognitive and social problems experienced by patients co...