I feel honored to be asked by the Movement Disorders journal to contribute my thoughts to the controversy on how to treat patients with Wilson’s disease, particularly during the initial period. I am doubly honored to cross swords on this topic with Professor John Walshe, who has contributed so much to the treatment of Wilson’s disease. As I have said in other settings, a whole generation of pat...

Thyroid hormone (T3) increases the transcription of the sarcoplasmic reticulumCa adenosine triphosphatase (ATPase) gene (SERCA 2) through three thyroid hormone response elements. The existence of repetitive cis elements with different configurations is likely to serve specific functions such as interactions with nuclear transcription factors. In addition, the presence of different T3 receptor i...

In this regard, the temporal pattern of myocardial contrast enhancement on MRI is reported in this issue of Circulation to be a predictive index of potential myocardial viability for reperfused myocardial infarctions.1 With fast MRI, the firstpass distribution of MRI contrast media indicated that despite patency of the target coronary artery with TIMI 3 flow in all patients, reperfusion at the ...

Objective: Evaluate the consistency of the contribution of interactions between single nucleotide polymorphism (SNP) genotype eff ects to variation in measures of lipid metabolism across ethnic strata within gender. Methods and Results: We considered 80 SNPs within the apolipoprotein (APO) A1/C3/A4/A5 gene cluster using an over-parameterized general linear model to identify SNPs whose genotype ...

Program Number: 6585 Poster Board Number: D0356 Presentation Time: 11:00 AM–12:45 PM Novel RS1 Mutation in an Irish X-Linked Retinoschisis Cohort Kirk Stephenson1, Matthew Carrigan2, Paul Kenna3, 2, G Jane Farrar2, David Keegan1. 1Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland; 2Trinity College Dublin, Dublin, Ireland; 3Ophthalmology, Royal Victoria Eye & Ear Hospital, ...

•Empirically validated probabilistic forecasts of energy technology costs•Future system costs are estimated for three different scenarios•A rapid green transition will likely result in trillions net savings•Energy models should be updated to reflect high probability low-cost renewables Decisions about how and when decarbonize the global highly influenced by estimates cost. Most energy-economy h...

BACKGROUNDAND PURPOSE: The differentiation of pilocytic astrocytomas and high-grade astrocytomas is sometimes difficult. There are limited comparisons in the literature of the advanced MR imaging findings of pilocytic astrocytomas versus high-grade astrocytomas. The purpose of this study was to assess the MR imaging, PWI, DWI, and MR spectroscopy characteristics of pilocytic astrocytomas compar...