The in vitro activity of PA-824 and BTZ043 against 30 Nocardia brasiliensis isolates was tested. The MIC(50) and MIC(90) values for PA-824 were both >64 μg/ml. The same values for BTZ043 were 0.125 and 0.250 μg/ml. Given the MIC values for benzothiazinone (BTZ) compounds, we consider them good candidates to be tested in vivo against N. brasiliensis.

BACKGROUND Endothelin-1 (ET-1) has been implicated in the pathophysiology of chronic kidney disease (CKD) and ET receptor blockade has shown renoprotective effects in animals. We examined the haemodynamic and renal effects of an ET receptor antagonist, TAK-044, in patients with CKD. METHODS Seven patients with CKD (mean arterial pressure 103 mmHg; mean plasma creatinine 3.5 mg/dl) received th...

* Corresponding Author 11 Department of Genetics 12 Dr ALMPGIBMS 13 University of Madras 14 Taramani Campus 15 Chennai 600113 16 Phone: 91-044-24925317 17 Fax : 91-044-24926709 18 E-mail: [email protected] 19 20 Running Title: Anti mycoplasma activity of ER-2 21 22 23 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Ant...

Abstract In December 2019, the latest generation transportable superconducting gravimeter (SG) iGrav-043 purchased by University of Bonn was installed in Walferdange Underground Laboratory for Geodynamics (WULG) Grand Duchy Luxembourg. this paper, we estimate calibration factor iGrav-043, which is essential long-term gravity monitoring. We used simultaneously collected data from un-calibrated a...

The effect of an endothelin (ET) A/ETB receptor antagonist, TAK-044, and/or an angiotensin converting enzyme (ACE) inhibitor, temocaprilat, on myocardial metabolism and contraction during ischemia and reperfusion was examined by phosphorus 31-nuclear magnetic resonance (31P-NMR) in Langendorff rabbit hearts. After normothermic 15 min global ischemia, 60min of postischemic reperfusion was carrie...

Although ET-1 antagonists have been beneficial in the treatment of heart failure (HF), their involvement in the effect on the sympathetic nervous system in HF remains unknown. The present study investigated the role of endogenous endothelin (ET) in the sympathetic nervous system in HF by observing the effect of ET AB antagonist (TAK-044) on renal sympathetic nerve activity (RSNA) in conscious r...

We analyze a high-resolution, high signal-to-noise spectrum of the carbon-rich, extremely metal-poor star CS 29498–043, obtained with the Subaru Telescope High Dispersion Spectrograph. We find its iron abundance is extremely low ([Fe/H] = −3.7), placing it among the few stars known with [Fe/H] ≤ −3.5, while Mg and Si are significantly overabundant ([Mg/Fe] = +1.8, and [Si/Fe] = +1.1) compared w...

It is well known that the optimal solution for searching in a nite total order set is the binary search. In the binary search we divide the set into two \halves", by querying the middle element, and continue the search on the suitable half. What is the equivalent of binary search, when the set P is partially ordered? A query in this case is to a point x 2 P , with two possible answers: 'yes', i...

S.A. was supported by the CIDEGENT Program from Generalitat Valenciana CIDEGENT/2019/043.