BACKGROUND The discovery of potent and broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) has made passive immunization a potential strategy for the prevention and treatment of HIV infection. We sought to determine whether passive administration of VRC01, a bNAb targeting the HIV CD4-binding site, can safely prevent or delay plasma viral rebound after the discont...

Mutations in the human Tsc1 and Tsc2 genes predispose to tuberous sclerosis complex (TSC), a disorder characterized by the wide spread of benign tumors. Tsc1 and Tsc2 proteins form a complex and serve as a GTPase-activating protein (GAP) for Rheb, a GTPase regulating a downstream kinase, mTOR. The genome of Schizosaccharomyces pombe contains tsc1 and tsc2, homologs of human Tsc1 and Tsc2, respe...

Through persuasive communications, information technology (IT) executives hope to align the actions of end users with the expectations of senior management and of the firm regarding technology usage. One highly influential factor of persuasive effectiveness is the source of the persuasive message. This study presents a conceptual model for explaining the influence of source credibility on end u...

End User Development offers technological flexibility to encourage the appropriation of software applications within specific contexts of use. Appropriation needs to be understood as a phenomenon of many collaborative and creative activities. To support appropriation, we propose integrating communication infrastructure into software application that follows an“easy-to-collaborate”-principle. Su...

0140-3664/$ see front matter 2008 Elsevier B.V. A doi:10.1016/j.comcom.2008.03.016 * Corresponding author. Tel.: +49 30 3463 7378; fa E-mail addresses: [email protected] fraunhofer.de (G. Zhang), [email protected] (D. Gen (G. Kambourakis), [email protected] (T. Dagiuklas), jiri. [email protected] (D. Sisalem). The emergence of Voice over IP (VoIP) has offered numerous advantag...