Small-molecule inhibitors of Hsp90 show promise in the treatment of castrate-resistant prostate cancer (CRPC); however, these inhibitors trigger a heat shock response that attenuates drug effectiveness. Attenuation is associated with increased expression of Hsp90, Hsp70, Hsp27, and clusterin (CLU) that mediate tumor cell survival and treatment resistance. We hypothesized that preventing CLU ind...

We present the results of calculations of surface relaxations, energetics, and bonding properties for CaTiO3 001 and 011 surfaces using a hybrid description of exchange and correlation. We consider both CaO and TiO2 terminations of the nonpolar 001 surface and Ca, TiO, and O terminations of the polar 011 surface. On the 001 surfaces, we find that all upper-layer atoms relax inward on the CaO-te...

it 011 a larger scale and I should be much obliged if you would publish this with the request that medical officers who are in charge of plague cases and are willing to try it, would communicate with me when I shall be pleased to send them some. The vaccine was made in the District Laboratory by kind permission of the A. D. P. H. of the N. W. F. Province. I would ask them when writing, to let m...

Prabha Balaram1,*, Smriti M Krishna1, Susan James2, Vino. T. Cheriyan1, Sreelekha Therakathinal Thankappan1, Aleyamma Mathew3 Division of Cancer Research, Regional Cancer Centre, Medical College. P.O, Trivandrum 695 011, Kerala, India. Department of ENT, Medical College, Trivandrum 695-011, Kerala, India Department of Statistics, Regional Cancer Centre, Trivandrum, Kerala, India _______________...

The effect of multi-directional forging on the development texture and increase hardness was investigated for a commercial A5052 aluminum alloy, which had an initial with major orientation ｛001｝<100>. Two specimens were prepared: one obtained via (MDF) performed four times at true strain 0.18 each forging, while other prepared unidirectional (UDF) time 0.72. MDF UDF same 0.72 exhibited tendenci...

In this study, the strain distribution in grains with a preferred orientation cold-rolled steel plate was investigated. This done by measuring amount of region material using nanoscale fine markers applied focused ion beam (FIB). We obtained crystal orientations and distributions same scanning electron microscopy-electron backscatter diffraction made FIB during rolling to 60% 70% thickness redu...

This issue of the journal is devoted to the themes of Geometry, Combinatorial Designs and Cryptology. The guest editors selected sixteen contributions covering various areas within these themes, ranging from public-key cryptography to matters related to key distribution and authentication, from problems in graph theory to resolvability issues in designs, from finite projective planes to higher-...

BACKGROUND Astaxanthin is the most important and expensive carotenoid pigment used in aquaculture. Its commercial attractiveness is also related with its antioxidant potential. Xanthophyllomyces dendrorhous yeast is considered to be promising for commercial production of astaxanthin. The aim of this study was to investigate the possibility of the growth and astaxanthin production by X. dendrorh...