O VULATION rate, follicular development, anterior pituitary gland weight and corpora lutea weight were studied in a total of 74 puberal gilts of the Poland China and Yorkshire breeds and their reciprocal crosses. The effects of two levels of feeding also were studied for the first 16 days of the puberal estrous cycle in half of the gilts and for the puberal estrous cycle plus 3 days of the succ...

The effect of the pericardium on the end-systolic pressure-segment length relationship in the left ventricle was examined with an ultrasonic miniature gauge in open-chest dogs. In 12 dogs, blood was infused until left ventricular (LV) end-diastolic pressure reached about 20 mm Hg, and then the pericardium was opened widely. In the other 12 dogs a pericardiectomy was performed without blood infu...

To determine if excessive osteoclastic-mediated bone resorption (BR) is an early tumor-induced event in multiple myeloma (MM), BR was assessed at first presentation on quantitative bone biopsy in 87 individuals evaluated for monoclonal gammopathy of undetermined significance (MGUS) and reinterpreted according to the presenting features and subsequent follow-up evaluation. As a reference populat...

PURPOSE To investigate agreement in intraocular pressure (IOP) measurements among Icare rebound tonometry, Tonopen tonometry, and Goldmann applanation tonometry following vitreoretinal surgery. DESIGN Reliability analysis of tonometers. METHODS Fifty-eyes of 50 adults undergoing vitreoretinal surgery were enrolled. IOP was measured on first postoperative day using Icare (Tiolat, Helsinki, F...

Age-related changes in cardiovascular regulatory mechanisms may affect blood pressure homeostasis during sleep and in the daytime. This study compared systemic hemodynamics during the daytime and sleep between 12 young or middle-aged patients (young, 42.1 +/- 13.9 years old, mean +/- SD, less than 56 years old) and 12 elderly patients with essential hypertension (old, 65.3 +/- 2.8, 60 to 70 yea...

OBJECTIVE Postprandial symptoms in irritable bowel syndrome are common and relate to an exaggerated motor and sensory component of the gastrocolonic response. We investigated whether this response can be affected by hypnotherapy. METHODS We included 28 patients with irritable bowel syndrome refractory to other treatments. They were randomized to receive gut-directed hypnotherapy 1 hour per we...

BACKGROUND AND OBJECTIVES Although considerable experimental and clinical knowledge exists on the physiology of pneumoperitoneum, insufflation of the preperitoneal space has not been extensively studied. The purpose of this study is to evaluate the physiology associated with preperitoneal carbon dioxide (CO2) insufflation in a porcine model. METHODS Eleven pigs weighing 35 to 45 kg were anest...

We have recently reported that the cardiovascular responses to excitatory amino acids are augmented in the rostral ventrolateral medulla of spontaneously hypertensive rats (SHR). In the present study, we investigated whether the responsiveness to excitatory amino acids would be normalized by antihypertensive treatment. Thus we treated 4-week-old SHR and age-matched Wistar-Kyoto (WKY) rats with ...

Interactions between pharmacologic NF-kappaB inhibitors (eg, Bay 11-7082, SN-50) and the checkpoint abrogator UCN-01 have been examined in human multiple myeloma (MM) cells. Exposure of U266 cells to Bay 11-7082 (Bay) in combination with UCN-01 resulted in the abrogation of NF-kappaB/DNA binding activity and the synergistic induction of apoptosis. Comparable synergism was observed in other MM c...

Purpose ; Effects of topically applied 0.1% dernmethrsone on epithelirl and endothelial healing following alkali wound were examined. Mehtods ; 30 New Zealand white rabbits were divided in 3 groups. By using a 5.5 mm round filter paper, alkali wounds ( 1N NaOH, 60s ) were produced in one eye of each animal. Group A treated with 0.1% dexamethasone, 3 x/day for 3 weeks. Group B received 0.1% dexa...