A tetrameric recombinant major histocompatibility complex (MHC) class I-peptide complex was used as a staining reagent in flow cytometric analyses to quantitate and define the phenotype of Gag-specific cytotoxic T lymphocytes (CTLs) in the peripheral blood of simian immunodeficiency virus macaque (SIVmac)-infected rhesus monkeys. The heavy chain of the rhesus monkey MHC class I molecule Mamu-A*...

BACKGROUND UCN-01, a Chk1 inhibitor, abrogates S and G(2) arrest and enhances cancer cell killing by DNA-damaging drugs in preclinical models. UCN-01 avidly binds alpha1-acid glycoprotein in plasma; whether sufficient drug concentrations are achieved in human tumors is unknown. A phase I trial tested the hypothesis that UCN-01 abrogates cisplatin-induced cell cycle arrest (in tumors) at tolerab...

The use of the creatine kinase-luciferase (CK-L) coupled reaction for porcine blood CK determination was studied. Adenosine triphosphate produced by CK is reacted with firefly L light-producing system. The method permits determination of CK in blood as opposed to traditional methods which require plasma or serum. The luciferase procedure was applied to nine barrows each of purebred Pietrain and...

Single crystals of the title compounds were prepared by solid-solid reaction using BaCl2 or BaBr2 flux at 1100°C. The structures of these two new cobaltites were solved and refined in the trigonal symmetry with space group R3 m: a=5.716(2) Å, c=45.01(3) Å for Ba2Co4ClO7 and a=5.7434(5) Å, c=46.151(9) Å for Ba2Co4BrO7. The two compounds are isostructural and their structures can be considered as...

Single crystals of the new barium hollandite Ba1.3Co1.3Ti6.7O16 were obtained from a BaCl2 flux (I2/m, Z = 1, a = 9.9470(4), b = 2.9714(2), c = 10.2260(5) Å, β = 90.906(2)◦). In the crystal structure piles of Ba atoms are situated within a framework of edgeand vertex-sharing octahedra (Co,Ti)O6. The composition was deduced from microprobe analyses, structure refinements and charge balance argum...

BACKGROUND Atrial fibrillation (AF) arises from abnormalities in atrial structure and electrical activity. Microelectrode arrays (MEA) is a real-time, nondestructive measurement of the resting and action potential signal, from myocardial cells, to the peripheral circuit of electrophysiological activity. This study examined the field action potential duration (fAPD) of the right atrial appendage...

To assess the utility of laser altimetry for studies in dynamical oceanography, we present a comparison of the Shuttle Laser Altimeter (SLA)-01 and the TOPEX/POSEIDON (T/P) radar altimeter on global and regional scales. We compare all 1.1 million SLA-01 range measurements over the oceans to the CSRMSS95 gridded mean sea surface model and find the overall root mean square (RMS) difference to be ...