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Introduction: Worldwide, >200 million patients are affected by peripheral arterial disease (PAD) and endovascular interventional treatments increasingly being applied. Contrast-induced nephropathy (CIN) is the third most common cause of renal failure in hospitals. However, factors such as vasoconstriction, decrease blood flow, endothelial dysfunction, oxidative stress have been suggested...
Natural killer (NK) cells play a key role in immunity, but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism impacts disease outcome remains unclear. KIR3DL1 (*001/*005/*015) tetramers were screened for reactivity against a panel of HLA-I molecules. This revealed different and distinct hierarchies of specificity for each KIR3DL1 allotype, with KIR3...
The design, synthesis, and evaluation of the potency of new isoform-selective inhibitors of sphingosine kinases 1 and 2 (SK1 and SK2), the enzyme that catalyzes the phosphorylation of d-erythro-sphingosine to produce the key signaling lipid, sphingosine 1-phosphate, are described. Recently, we reported that 1-(4-octylphenethyl)piperidin-4-ol (RB-005) is a selective inhibitor of SK1. Here we rep...
Twenty-five crossbred gilts were used in an experiment to determine the tryptophan (Trp) requirement for reproduction. L-tryptophan was added to a fortified corn-gelatin diet to attain the five Trp levels of .64, 1.04, 1.44, 1.84 and 2.24 g per day. These diets were fed at 2 kg daily during pregnancy I and 1.82 kg daily during pregnancies II and III. During each 3-week lactation, all animals we...
Long non-coding RNAs (lncRNAs) have shown great potential as powerful and non-invasive tumor markers. However, little is known about their value as biomarkers in pancreatic cancer (PC). We applied an Arraystar Human LncRNA Microarray which targeting 7419 lncRNAs to determine the lncRNA expression profile in PC and to screen the potential biomarkers. The most increased lncRNAs in PC tissues were...
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